Symposium 14: Preservation of beta cell at diagnosis
DOI:
https://doi.org/10.47196/diab.v54i3Sup.715Keywords:
diabetes, beta cellAbstract
Symposium 14: When does type 1 diabetes mellitus begin?
Preservation of beta cell at diagnosis
Through the years, we have learnt that type 1 diabetes is a heterogeneous disease in its presentation, evolution and that its development depends on the interrelationship between genetic, immunologic and environmental factors. During the development stages of type 1 diabetes we can observe the genetic predisposition with autoimmune expression in beta-cell (stage 1), the appearance of dysglycemia (stage 2) and it becoming clinically symptomatic (stage 3), but little is known about the sequential changes in insulin secretion and glucose homeostasis through these stages. TrialNEt shows the variation of PEPC six months before the clinical diagnosis and then, after it. It is know that the dysfunction of beta-cells in type 1 diabetes might precede diagnosis for over 5 years. Most patients with long term type 1 diabetes are micro secretors of insulin, have a functional beta-cell that answers to stimuli and the partial clinical remission is inversely correlated to ketoacidosis and directly with BMI and age at the time of diagnosis.
References
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