PUBLICIDAD

Comité de Oftalmopatía. ¿Es la patología oftálmica en diabetes una herramienta útil para categorizar el riesgo cardiovascular?

Autores/as

  • Claudia Marcela Issa Sanatorio Güemes, Ciudad Autónoma de Buenos Aires, Argentina
  • María Candelaria Domina Medical Science Liaison Boehringer-Ingelheim (Argentina-Paraguay-Uruguay), Ciudad Autónoma de Buenos Aires, Argentina
  • María Laura Payero Hospital Municipal San Cayetano, San Fernando, Provincia de Buenos Aires, Argentina
  • Santiago Lima Centro CEDIAB La Plata, Provincia de Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v58i1Sup.766

Palabras clave:

riesgo cardiovascular, retinopatía, edema macular

Resumen

Actualmente nadie duda que la aparición de complicaciones microvasculares en la diabetes mellitus (DM) está relacionada con la hiperglucemia crónica. En la recientemente publicada guía de la European Society of Cardiology (ESC) 2023 para el manejo de la enfermedad cardiovascular (ECV) en DM, se establece nuevamente que la presencia de la retinopatía diabética (RD) junto con la nefropatía y la neuropatía colocan al paciente en categoría de muy alto riesgo cardiovascular. Categorizar correctamente el riesgo cardiovascular del paciente nos permite prevenir y/o retrasar eventos cardiovasculares mayores, y tomar precauciones adecuadas frente a intervenciones quirúrgicas para evitar complicaciones intra o perioperatorias. La recomendación de este Comité, previo al inicio de la medicación para la DM, es realizar una evaluación oftalmológica completa que incluya fondo de ojo y otros estudios oftalmológicos, como la retinofluoresceinografía y la tomografía de coherencia óptica, para la mejor categorización del riesgo de la persona con DM y la elección adecuada de la medicación a iniciar para el control glucémico.

Biografía del autor/a

Claudia Marcela Issa, Sanatorio Güemes, Ciudad Autónoma de Buenos Aires, Argentina

Médica especialista en Medicina Interna y Nutrición, Magíster en Diabetes, Diplomada en Cicatrización de Heridas, Coordinadora del Comité de Oftalmopatía, Sociedad Argentina de Diabetes (SAD), Coordinadora de Diabetología

María Candelaria Domina, Medical Science Liaison Boehringer-Ingelheim (Argentina-Paraguay-Uruguay), Ciudad Autónoma de Buenos Aires, Argentina

Médica especialista en Medicina Interna y Nutrición, Magíster en Diabetes

María Laura Payero, Hospital Municipal San Cayetano, San Fernando, Provincia de Buenos Aires, Argentina

Médica especialista en Medicina General y Familiar, especialista en Nutrición

Santiago Lima, Centro CEDIAB La Plata, Provincia de Buenos Aires, Argentina

Médico especialista en Medicina Interna, Magíster en Diabetes

Citas

I. Bianchi C, Del Prato S. Metabolic memory and individual treatment aims in type 2 diabetes outcome-lessons learned from large clinical trials. Rev Diabet Stud 2011;8(3):432-40.

II. Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, et al.; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005;353(25):2643-53.

III. Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, Federici M, Filippatos G, Grobbee DE, Hansen TB, Huikuri HV, Johansson I, Jüni P, Lettino M, Marx N, Mellbin LG, Östgren CJ, Rocca B, Roffi M, Sattar N, Seferović PM, Sousa Uva M, Valensi P, Wheeler DC; ESC Scientific Document Group. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J 2020 Jan 7;41(2):255-323. doi: 10.1093/eurheartj/ehz486.

IV. Das SR, Everett BM, Birtcher KK, Brown JM, Januzzi JL Jr, Kalyani RR, Kosiborod M, Magwire M, Morris PB, Neumiller JJ, Sperling LS. 2020 Expert consensus decision pathway on novel therapies for cardiovascular risk reduction in patients with type 2 diabetes. A report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037.

V. Marx N, Federici M, Schütt K, Müller-Wieland D; ESC Scientific Document Group. ESC Guidelines for the management of cardiovascular disease in patients with diabetes: Developed by the task force on the management of cardiovascular disease in patients with diabetes of the European Society of Cardiology (ESC). European Heart Journal 2023;44(39):4043-4140. doi: 10.1093/eurheartj/ehad192.

VI. Davis MD, Hiller R, Magli YL, Podgor MJ, Ederer F, Harris WA, et al. Prognosis for life in patients with diabetes: relation to severity of retinopathy. Trans Am Ophthalmol Soc 1979;77:144-70.

VII. Juutilainen A, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women. Diabetes Care 2007;30(2): 292-9.

VIII. Cheung N, Rogers S, Couper DJ, Klein R, Sharrett AR, Wong TY. Is diabetic retinopathy an independent risk factor for ischemic stroke? Stroke 2007;38(2):398- 401.

IX. Guo VY, Cao B, Wu X, Lee JJW, Zee BC. Prospective association between diabetic retinopathy and cardiovascular disease. A systematic review and meta-analysis of cohort studies. J Stroke Cerebrovasc Dis 2016 Jul;25(7):1688-1695. doi: 10.1016/j.jstrokecerebrovasdis.2016.03.009.

X. Zhu XR, Zhang YP, Bai L, Zhang XL, Zhou JB, Yang JK. Prediction of risk of diabetic retinopathy for all-cause mortality, stroke and heart failure: Evidence from epidemiological observational studies. Medicine (Baltimore). 2017 Jan;96(3):e5894. doi: 10.1097/MD.0000000000005894.

XI. Cooper LS, Wong TY, Klein R, Sharrett AR, Bryan RN, Hubbard LD, et al. Retinal microvascular abnormalities and MRI-defined subclinical cerebral infarction: the Atherosclerosis Risk in Communities Study. Stroke 2006;37(1):82-6.

XII. Ho H, Cheung CY, Sabanayagam C, Yip W, Ikram MK, Ong PG, Mitchell P, Chow KY, Cheng CY, Tai ES, Wong TY. Retinopathy signs improved prediction and reclassification of cardiovascular disease risk in diabetes: a prospective cohort study. Sci Rep. 2017 Feb 2;7:41492. doi: 10.1038/srep41492

XIII. Kawasaki R, Tanaka S, Tanaka S, Abe S, Sone H, Yokote K, et al.; Japan Diabetes Complications Study Group. Risk of cardiovascular diseases is increased even with mild diabetic retinopathy: the Japan Diabetes Complications Study. Ophthalmology 2013;120(3):574-82.

XIV. Kramer CK, Rodrigues TC, Canani LH, Gross JL, Azevedo MJ. Diabetic retinopathy predicts all-cause mortality and cardiovascular events in both type 1 and 2 diabetes: meta-analysis of observational studies. Diabetes Care 2011 May;34(5):1238-44. doi: 10.2337/dc11-0079.

XV. Garofolo M, Gualdani E, Giannarelli R, Aragona M, Campi F, Lucchesi D, Daniele G, Miccoli R, Francesconi P, Del Prato S, Penno G. Microvascular complications burden (nephropathy, retinopathy and peripheral polyneuropathy) affects risk of major vascular events and all-cause mortality in type 1 diabetes: a 10-year follow-up study. Cardiovasc Diabetol 2019 Nov 16;18(1):159. doi: 10.1186/s12933-019-0961-7.

XVI. Gimeno-Orna JA, Faure-Nogueras E, Castro-Alonso FJ, Boned-Juliani B. Ability of retinopathy to predict cardiovascular disease in patients with type 2 diabetes mellitus. Am J Cardiol 2009 May 15;103(10):1364-7. doi: 10.1016/j.amjcard.2009.01.345.

XVII. Xie J, Ikram MK, Cotch MF, Klein B, Varma R, Shaw JE, Klein R, Mitchell P, Lamoureux EL, Wong TY. Association of diabetic macular edema and proliferative diabetic retinopathy with cardiovascular disease: a systematic review and meta-analysis. JAMA Ophthalmol 2017 Jun 1;135(6):586-593. doi: 10.1001/jamaophthalmol.2017.0988.

XVIII. Gerstein HC, Ambrosius WT, Danis R, Ismail-Beigi F, Cushman W, Calles J, et al. ACCORD Study Group. Diabetic retinopathy, its progression, and incident cardiovascular events in the ACCORD trial. Diabetes Care 2013;36(5):1266-71.

XIX. Damkondwar DR, Raman R, Suganeswari G, Kulothungan V, Sharma T. Assessing Framingham cardiovascular risk scores in subjects with diabetes and their correlation with diabetic retinopathy. Indian J Ophthalmol 2012;60(1):45-8.

XX. Cheung N, Wang JJ, Rogers SL, Brancati F, Klein R, Sharrett AR, Wong TY; ARIC (Atherosclerosis Risk In Communities) Study Investigators. Diabetic retinopathy and risk of heart failure. J Am Coll Cardiol. 2008 Apr 22;51(16):1573-8. doi: 10.1016/j.jacc.2007.11.076.

XXI. Sabanayagam C, Chee ML, Banu R, Cheng CY, Lim SC, Tai ES, Coffman T, Wong TY. Association of diabetic retinopathy and diabetic kidney disease with all cause and cardiovascular mortality in a multiethnic asian population. JAMA Netw Open 2019 Mar 1;2(3):e191540. doi: 10.1001/jamanetworkopen.2019.1540.

XXII. American Diabetes Association Professional Practice Committee. 9. Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes-2024. Diabetes Care 2024 Jan 1;47(Suppl 1):S158-S178. doi: 10.2337/dc24-S009.

XXIII. American Diabetes Association Professional Practice Committee. 10. Cardiovascular disease and risk management: Standards of Care in Diabetes 2024. Diabetes Care. 2024 Jan 1;47(Suppl 1):S179-S218. doi: 10.2337/dc24-S010.

XXIV. American Diabetes Association Professional Practice Committee. 12. Retinopathy, neuropathy, and foot care: Standards of Care in Diabetes-2024. Diabetes Care. 2024 Jan 1;47(Suppl 1):S231-S243. doi: 10.2337/dc24-S012.

XXV. Bethel MA, Diaz R, Castellana N, Bhattacharya I, Gerstein HC, Lakshmanan MC. HbA1c change and diabetic retinopathy during GLP-1 receptor agonist cardiovascular outcome trials: a meta-analysis and meta-regression. Diabetes Care 2021 Jan;44(1):290-296. doi: 10.2337/dc20-1815.

XXVI. Novo Nordisk A/S. A research study to look at how semaglutide compared to placebo affects diabetic eye disease in people with type 2 diabetes (FOCUS); [about 9 screens]. In: ClinicalTrials.gov. Bethesda, MD, National Library of Medicine (US), 2000. NLM Identifier: NCT03811561. Accessed 11 September 2020. Disponible en: https://clinicaltrials.gov/ct2/show/NCT03811561.

XXVII. Inzucchi SE, Wanner C, Hehnke U, Zwiener I, Kaspers S, Clark D, George JT, Zinman B. Retinopathy outcomes with empagliflozin vs placebo in the EMPA-REG OUTCOME Trial. Diabetes Care 2019 Apr;42(4):e53-e55. doi: 10.2337/dc18-1355.

XXVIII. Yen F, Wei JC, Yu T, Hung Y, Hsu C, Hwu C. Sodium-glucose cotransporter 2 inhibitors and risk of retinopathy in patients with type 2 diabetes. JAMA Netw Open 2023;6(12):e2348431. doi:10.1001/jamanetworkopen.2023.48431.

XXIX. Li JX, Hung YT, Bair H, Hsu SB, Hsu CY, Lin CJ. Sodium-glucose co-transporter 2 inhibitor add-on therapy for metformin delays diabetic retinopathy progression in diabetes patients: a population-based cohort study. Sci Rep 2023 Oct 10;13(1):17049. doi: 10.1038/s41598-023-43893-2.

Descargas

Publicado

01-04-2024

Cómo citar

Issa, C. M., Domina, M. C., Payero, M. L., & Lima, S. (2024). Comité de Oftalmopatía. ¿Es la patología oftálmica en diabetes una herramienta útil para categorizar el riesgo cardiovascular? . Revista De La Sociedad Argentina De Diabetes, 58(1Sup), 46–49. https://doi.org/10.47196/diab.v58i1Sup.766

Número

Sección

Recomendaciones

Artículos similares

También puede {advancedSearchLink} para este artículo.

Artículos más leídos del mismo autor/a