Transplant Committee. Long-term clinical monitoring of β-cell functionality in patients with renopancratic transplant or isolated pancreas

Authors

  • Javier Giunta Favaloro Foundation, Autonomous City of Buenos Aires, Argentina
  • Luis A. Grosembacher Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v58i1Sup.768

Keywords:

pancreatic transplant, renopancreas transplant, ß cell function

Abstract

Introduction: renopancreas and isolated pancreas transplantation represent an effective biological treatment for patients with type 1 diabetes and end-stage renal disease. These procedures aim to restore the function of pancreatic ß cells. However, the long-term success of these transplants requires appropriate clinical monitoring to detect potential complications and ensure optimal ß cell function.

Recommendations: for monitoring purposes, we have clinical tools to assess glycemic control and potential biological insults. It is recommended to assess glycemic control using fasting glucose, HbA1c, glucose tolerance tests, and C-peptide. Amylase and lipase serve as markers for subclinical insults against the transplanted pancreas. The interpretation of these tools defines four functional stages: optimal, adequate, marginal, and failure. During follow-up, it is advisable to maintain measures for the prevention and treatment of microvascular and macrovascular complications.

Conclusions: hese monitoring recommendations for renopancreas and isolated pancreas transplant patients are essential for evaluating ß cell functionality and reducing the risk of long-term complications.

Author Biographies

Javier Giunta, Favaloro Foundation, Autonomous City of Buenos Aires, Argentina

Cardiologist, Coordinator of the Transplant and Stem Cells Committee, Argentine Diabetes Society (SAD), Clinical Cardiology Service, René G Favaloro University Hospital

Luis A. Grosembacher, Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Endocrinologist, Head of the Diabetes Section, Endocrinology, Metabolism and Nuclear Medicine Service

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Revista de la Sociedad Argentina de Diabetes: Suplemento Recomendaciones de los Comités de Trabajo de la SAD

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Published

2024-04-01

How to Cite

Giunta, J., & Grosembacher, L. A. (2024). Transplant Committee. Long-term clinical monitoring of β-cell functionality in patients with renopancratic transplant or isolated pancreas. Journal of the Argentine Society of Diabetes, 58(1Sup), 50–52. https://doi.org/10.47196/diab.v58i1Sup.768

Issue

Vol. 58 No. 1Sup (2024): January/April 2024

Section

Recommendations

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Copyright (c) 2024 on behalf of the authors. Reproduction rights: Argentine Diabetes Society

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