Skeletal muscle lipotoxicity, a way to investigate

Authors

  • Gabriela Berg Faculty of Pharmacy and Biochemistry and Institute of Physiopathology and Clinical Biochemistry, University of Buenos Aires; National Council for Scientific and Technical Research (CONICET); Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v53i2.146

Keywords:

metabolic syndrome, sucrose rich diet, skeletal muscle, insulin resistant, lipotoxicity

Abstract

For those who read an editorial in the Journal of the Argentine Diabetes Society, they know that type 2 diabetes mellitus (DM2) is a complex disease, generated from multiple pathophysiological processes that still attract debate. What is out of the question, at this level of knowledge, is the theory that "ectopic fat", accumulated in cells other than adipocytes, leads to organ-specific insulin resistance known as lipotoxicity.

Author Biography

Gabriela Berg, Faculty of Pharmacy and Biochemistry and Institute of Physiopathology and Clinical Biochemistry, University of Buenos Aires; National Council for Scientific and Technical Research (CONICET); Autonomous City of Buenos Aires, Argentina

Prof. Associate of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry (University of Buenos Aires); Independent Health Researcher of the National Council for Scientific and Technical Research (CONICET), Lipids and Atherosclerosis Laboratory, Institute of Physiopathology and Clinical Biochemistry, University of Buenos Aires

References

Cusi K. The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes. Curr Diab Rep 2010; 10:306-315.

Ferrara D, Montecucco F, Dallegri F, Carbone F. Impact of different ectopic fat depots on cardiovascular and meta¬bolic diseases. J Cell Physiol 2019; 1-12.

Consitt LA, Bell JA, Houmard JA. Intramuscular lipid metabolism, insulin action, and obesity. IUBMB. Life 2009; 61, 47-55.

Randle P, Garland P, Newsholme EA, Hales C. The glu¬cose fatty acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963;1:785-789.

Metcalfe LK, Smith GC, Turner N. Defining lipid media¬tors of insulin resistance. Controversies and challenges. J Mol Endocrinol 2018; 62, R65-R82.

Miksztowicz V, Schreier L, McCoy M, Lucero D, Fassio E, Billheimer J, Rader DJ, Berg G. Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity. Arte¬rioscler Thromb Vasc Biol 2014 Mar; 34(3):669-75.

Barchuk M, Miksztowicz V, Zago V, Cevey A, López G, Goren N, Friedman S, Gelpi RJ, Morales C, Fernandez Tomé MDC, Schreier L, Berg G. Endothelial lipase is an alternative pathway for fatty acid release from lipopro¬teins: evidence from a high fat diet model of obesity in Rats. Lipids 2018 Oct; 53(10):993-1003.

Kiens B. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol Rev 2006; 86(1): 205-43.

Bandet CL, Tan-Chen S, Bourron O, Le Stunff H, Hajduch E. Sphingolipid metabolism: new insight into ceramide-induced lipotoxicity in muscle cells. Int J Mol Sci 2019 Jan 23; 20(3).

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Published

2023-01-10

How to Cite

Berg, G. (2023). Skeletal muscle lipotoxicity, a way to investigate. Journal of the Argentine Society of Diabetes, 53(2), 51–52. https://doi.org/10.47196/diab.v53i2.146

Issue

Vol. 53 No. 2 (2019): May/Agost 2019

Section

Editorial

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Dirección Nacional de Derecho de Autor, Exp. N° 5.333.129. Instituto Nacional de la Propiedad Industrial, Marca «Revista de la Sociedad Argentina de Diabetes - Asociación Civil» N° de concesión 2.605.405 y N° de disposición 1.404/13.

La Revista de la SAD está licenciada bajo Licencia Creative Commons Atribución – No Comercial – Sin Obra Derivada 4.0 Internacional.

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