Hipoglucemia hiperinsulinémica postprandial luego de la cirugía bariátrica
DOI:
https://doi.org/10.47196/diab.v53i1.137Palabras clave:
hipoglucemia hiperinsulinémica, hipoglucemia postprandial, cirugía bariátrica, bypass gástrico, dumping tardíoResumen
La incidencia de complicaciones informadas luego de la cirugía bariátrica (CB) ha ido en aumento en relación con la epidemia de obesidad y el mayor número de procedimientos quirúrgicos realizados a nivel mundial. Entre las complicaciones, la hipoglucemia hiperinsulinémica postprandial (HHP) adquirió relevancia, aunque es una de las menos conocidas y comprendidas de la cirugía bariátrica (CB), frecuentemente inadvertida y por lo tanto subdiagnosticada. Se distingue de la hipoglucemia de ayuno en que su presentación es típicamente posterior a la ingesta, asociada a valores de hipoglucemia precedidos por hiperglucemia e hiperinsulinemia en sangre. Se caracteriza por el incremento de la variabilidad de la glucemia, con absorción acelerada, aumento y caída rápida de azúcar en sangre, por lo que comprende valores de hiper e hipoglucemia. Debe sospecharse cuando se detectan síntomas adrenérgicos o de neuroglucopenia postprandiales luego de la CB1.
Ha sido considerada más frecuente luego del bypass gástrico en-Y-Roux (BGYR), pero también fue descripta asociada a otras técnicas quirúrgicas, como la derivación biliopancreática/switch duodenal (DBP/SD)2 y la gastrectomía vertical en manga (GVM), y de otras intervenciones que comprometen el píloro o el vaciamiento gástrico3. No se observó luego de la cirugía con banda gástrica ajustable, un procedimiento que no altera la anatomía gastrointestinal4-5.
Citas
Eisenberg D, Azagury D, Ghiassi S, et al. ASMBS. Position statement on postprandial hyperinsulinemic hypoglycemia after bariatric surgery. Surgery for Obesity and Related Diseases 2017; 13: 371-378.
Aasheim E, Frigstad SO, Søvik T, et al. Hyperinsulinemic hypoglycemia and liver cirrhosis presenting after duodenal switch: a case report. Surgery for Obesity and Related Diseases 2010; 6: 441-443.
Calabria AC, et al. Postoperative surveillance and detection of postprandial hypoglycemia after fundoplasty in children. J Pediatr 2011; 159 (4):597-601.
Lee CJ, Clark JM, Schweitzer M, et al. Prevalence of and risk factors for hypoglycemic symptoms after gastric bypass and sleeve gastrectomy. Obesity 2015; 23(5): 1079-84.
Scavini M, Pontiroli AE, Folli F. Asymptomatic hyperinsulinemic hypoglycemia after gastricbanding. N Engl J Med 2005; 353:2822-2823.
Berkowitz D, Glassman S. Carbohydrate metabolism in the subtotal gastrectomy patient. Am J Gastroenterol 1966; 46:119-29.
Service GJ, Thompson GB, Service FJ, et al. Hyperinsulinemic hypoglycemia with nesidioblastosis after gastric bypass surgery. NEJM 2005; 353(3):249-54.
Kellogg TA, Bantle JP, Leslie DB, et al. Post gastric bypass hyperinsulinemic hypoglycemia syndrome: characterization and response to a modified diet. Surg Obes Relat Dis 2008; 4 (4):492-499.
Laurenius A, Werling M, Le Roux C, et al. More symptoms but similar blood glucose curve after oral carbohydrate provocation in patients with a history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-en-Y gastric bypass. Surg Obes Relat Dis 2014; 10:1047-1055.
Vezzosi D, Bennet A, Fauvel J, et al. Insulin, C-peptide and proinsulin for the biochemical diagnosis of hypo-glycemia related to endogenous hyperinsulinism. Eur J Endocrinol 2007; 157: 75-83.
Lev-Ran A, Anderson RW. The diagnosis of postprandial hypoglycemia. Diabetes 1981; 30:996 -999.
Hanaire H, Bertrand M, Guerci B, et al. High glycemic variability assessed by continuous glucose monitoring after surgical treatment of obesity by gastric bypass. Diabetes Technol Ther 2011; 13:625-630.
Halperin F, Patti ME, Skow M, et al. Continuous glucose monitoring for evaluation of glycemic excursions after gastric bypass. J Obes 2011. Doi:10.1155/2011/869536.
Abrahamsson N, Eden-Engstrom B, Sundbom M, et al. Hypoglycemia in everyday life after gastric bypass and duodenal switch. Eur J Endocrinol. 2015 Jul;173(1):91-100.
Kefurt R, Langer F, Schindler K, et al. Hypoglycemia after Roux-En-Y gastric bypass: detection rates of continuous glucose monitoring (CGM) versus mixed meal test. Surg Obes Relat Dis 2015; 11:564-572.
Nielsen JB, Abild CB, Pedersen AM, et al. Continuous glucose monitoring after gastric bypass to evaluate the glucose variability after a low-carbohydrate diet and to determine hypoglycemia. Obes Surg 2016; 26(9): 2111-2118.
Malik S, Mitchell J, Steffen K, et al. Recognition and management of hyperinsulinemic hypoglycemia afterbariatric surgery. Review. Obes Res Clin Pract 2016; 10(1): 1-14.
Christfort-Øhrstrøm C, Worm D, Lindqvist-Hansen D. Postprandial hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass: an update. Surg Obes Relat Dis 2017; 13: 345-351.
Nannipieri M, Belligoli A, Guarino D, et al. Risk factors for spontaneously self-reported postprandial hypoglycemia after bariatric surgery. J Clin Endocrinol Metab 2016; 101 (10): 3600-3607.
Lee CJ, Wood GC, Lazo M, et al. Risk of post-gastric bypass surgery hypoglycemia in nondiabetic individuals: a single center experience. Obesity 2016; 24 (6): 1342-1348.
Mulla CM, Storino A, Yee EU, et al. Insulinoma after bariatric surgery: diagnostic dilemma and therapeutic approaches. Obes Surg 2016; 26:874-881.
Zagury L, Moreira RO, Guedes EP, Coutinho WF, Appolinario JC. Insulinoma misdiagnosed as dumping syndrome afterbariatric surgery. Obes Surg 2004; 14:120-123.
Kauhanen S, Seppänen M, Minn H, Gullichsen R, Salonen A, Alanen K, et al. Fluorine-18-L-dihydroxyphenylalanine (18F-DOPA) positron emission tomography as a tool to localize aninsulinoma or beta-cell hyperplasia in adult patients. J Clin Endocrinol Metab 2007; 92(4):1237-1244.
Rösch T, Lightdale CJ, Botet JF, et al. Localization of pancreatic tumors byendoscopic ultrasonography. N Engl J Med 1992; 326(26):1721-1726.
Doppman JL, Miller DL, Chang R, et al. Insulinomas: localization with selective intaarterial injection of calcium. Radiology 1991; 178(1):237-241.
Laferrere B, Reilly D, Arias S, et al. Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med. 2011;3:80re2.
Service FJ, Natt N, Thompson GB, et al. Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes. J Clin Endocrinol Metab 1999; 84(5): 1582-1589.
Marsk R, Jonas E, Rasmussen F, Naslund E. Nationwide cohort study of post-gastric bypass hypoglycaemia including 5,040 patients undergoing surgery for obesity in 1986-2006 in Sweden. Diabetologia 2010; 53: 2307-11.
Lee CJ, Clark JM, Schweitzer M, et al. Prevalence of and risk factors for hypoglycemic symptoms after gastric bypass and sleeve gastrectomy. Obesity 2015; 23(5): 1079-1084.
Harness JK, Geelhoed GW, Thompson NW, et al. Nesidioblastosis in adults. Arch Surg 1981; 116: 575-80.
Cui Y, Elahi D, Andersen DK. Advances in the etiology and management of hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass. J Gastrointest Surg 2011; 15: 1879-88.
Roth DA, Meade RC. Hyperinsulinism hypoglycemia in the postgastrectomy patient. Diabetes 1965; 14: 526-528.
Perfetti R, Zhou J, Doyle ME, et al. Glucagon-likepeptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000; 141:4600-4605.
Patti ME, Li P, Goldfine AB. Insulin response to oral stimuli and glucose effectiveness increased in neuro-glycopenia following gastric bypass. Obesity 2015; 23(4):798-807.
Meier JJ, Butler AE, Galasso R et al. Hyperinsulinemic hypoglycemia after gastric bypas surgery is not accompanied by islet cell hyperplasia or increased beta-cell turnover. Diabetes Care 2006; 29:1554-9.
Goldfine AB, Mun EC, Devine E, et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab 2007; 92: 4678-4685.
Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta analysis. Am J Med 2009; 122:248-256.
Beckman LM, Beckman TR, Sibley SD, et al Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery. J Parenter Enteral Nutr 2011; 35: 169-180.
Rariy CM, Rometo D, Korytkowski M. Post-gastric bypass hypoglycemia. Curr Diab Rep. 2016; 16(2):19.
Salehi M, Gastaldelli A, D’Alessio DA. Blockade of glucagon-like peptide-1 receptor corrects postprandial hypoglycemia aftergastric bypass. Gastroenterology 2014; 146(3):669-680.
Michaels A, Mehaffey H, French B, et al. Hypoglycemia following bariatric surgery: our 31-year experience. Obes Surg 2017; 27(12): 3118-3123.
Bantle A, Wang Q. Bantle J. Post gastric bypass hyperinsulinemic hypoglycemia fructose is a carbohydrate which can be safely consumed. J Clin Endocrinol Metab 2015; 100:3097-3102.
Millstein R, Lawler H. Hypoglycemia after gastric bypass: an emerging complication. Cleve Clin J Med 2017; 84 (4): 319-328.
Valderas JP, Ahuad J, Rubio L, et al. Acarbose improves hypoglycaemia following gastric by pass Surgery without increasing glucagon like peptide 1 levels. Obes Surg 2012; 22:582-586.
Ritz P, Vaurs C, Bertrand M, et al. Usefulness of acarbose and dietary modifications to limit glycemic variability following Roux en Y gastric bypass as assessed by continuous glucose monitoring. Diabetes Technology &Therapeutics 2012; 14:736-740
Tack J, Arts J, Caenepeel P, et al. Pathophysiology, diagnosis and management of postoperative dumping syndrome. Nat Rev Gastroenterol Hepatol 2009; 6:583-590.
Craig C, Liu L, Nguyen T, et al. Efficacy and pharmacokinetics of subcutaneous exendin (9-39) in patients with post-bariatric hypoglycaemia. Diabetes Obes Metab. 2018; 20:352-361.
Patti ME, Goldfine A. Hypoglycemia after gastric bypass: the dark side of GLP-1. Gastroenterology 2014; 146 (3): 605-608.
Abrahamsson N, Engstrom BE, Sundbom M, et al. GLP1 analogs as treatment of postprandial hypoglycemia following gastric bypass surgery: a potential new indication? Eur J Endocrinol 2013; 169(6): 885-889.
Jammah A. Endocrine and metabolic complications after bariatric surgery. Review article. Saudi J Gastroenterol 2015; 21:269-277.
Bernard B, Kline GA, Service FJ. Hypoglycemia following upper gastrointestinal surgery: case report and review ofthe literature. BMC Gastroenterol 2010; 10:77.
Ceppa EP, Ceppa DP, Omotosho PA, et al. Algoritm to diagnose etiology of hypoglycemia after Roux-en-Y gastric bypass for morbid obesity: case series and review of the literature. Surg Obes Relat Dis 2012; 8:641-647.
Mala T. Postprandial hyperinsulinemic hypoglycemia after gastric bypass surgical treatment. Review article. Surgery for Obesity and Related Diseases 2014; 10: 1220-1225.
Z'graggen K, Guweidhi A, Steffen R, et al. Severe recurrent hypoglycemia after gastric bypass surgery. Obes Surg 2008; 18: 981-988.
Campos G, Ziemelis M, Paparodis R, et al. Laparoscopic reversal of Roux-en-Y gastric bypass: Technique and utility for treatment of endocrine complications. Surg Obes Relat Dis 2014; 10: 36-43.
Shoar S, Nguyen T, Ona M, et al. Roux-en-Y gastric bypass reversal: a systematic review. Surg Obes Relat Dis 2016; 12: 1366-1372.
Zorron R, Branco A, Sampaio J, et al. One-anastomosis jejunal interposition with gastric remnant resection (Branco-Zorron Switch) for severe recurrent hyperinsulinemic hypoglycemia after gastric bypass for morbid obesity. Obes Surg 2017; 27:990-996.
Mc Laughlin T, Peck M, Holst J, et al. Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery. J Clin Endocrinol Metab 2010; 95:1851-1855.
Arora I, Patti ME. Can reversal of RYGB also reverse hypoglycemia? Molecular Metabolism 2018; 9: 1-3.
Mathavan VK, Arregui M, Davis C, et al. Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia. Surg Endosc 2010; 24: 2547-2555.
Singh E, Vella A. Hypoglycemia after gastric bypass surgery. Diabetes Spectr 2012; 25: 217-21.
Kirwan J, Aminian A, Kashyap S, et al. Bariatric surgery in obese patients with type 1 diabetes. Diabetes Care 2016; 39: 941-948.
Faucher P, Poitou C, Carette C, et al. Bariatric surgery in obese patients with type 1 diabetes: effets on weigth loss and metabolic control. Obes Surg 2016; 26: (10) 2370-2378.
Mahawar K, De Alwis N, Carr W, et al. Bariatric surgery in type 1 diabetes mellitus: a systematic review. Obes Surg 2016; (26): 196-204.
Chow A, Switzer N, Dang J, et al. A systematic review and meta-analisis of outcomes for type 1 diabetes after bariatric surgery. Journal of Obesity 2016.
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
Dirección Nacional de Derecho de Autor, Exp. N° 5.333.129. Instituto Nacional de la Propiedad Industrial, Marca «Revista de la Sociedad Argentina de Diabetes - Asociación Civil» N° de concesión 2.605.405 y N° de disposición 1.404/13.
La Revista de la SAD está licenciada bajo Licencia Creative Commons Atribución – No Comercial – Sin Obra Derivada 4.0 Internacional.
Por otra parte, la Revista SAD permite que los autores mantengan los derechos de autor sin restricciones.