Influence of intestinal microbiota on the development of type 1 diabetes mellitus Gustavo Frechtel

Authors

  • Gustavo Frechtel Clinics Hospital, University of Buenos Aires, City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v59i3.1272

Keywords:

gut microbiota, type 1 diabetes

Abstract

Type 1 diabetes mellitus (T1DM) is a multifactorial autoimmune disease caused by an interaction between genetic and environmental factors. Genetic susceptibility, which accounts for 50% of the risk of developing T1DM, is represented by variants (polymorphisms) in the sequence of genes of the major histocompatibility (HLA) system and non-HLA genes. These genes mostly encode molecules involved in the immune response, although the insulin gene is the second most common gene after HLA. Having a first-degree relative with T1DM increases the risk of developing it 15-fold, although only 10% to 15% of those affected have a family history.

Author Biography

Gustavo Frechtel, Clinics Hospital, University of Buenos Aires, City of Buenos Aires, Argentina

Nutrition specialist, Head of the Nutrition Division at the Clinics Hospital

References

I. Rich SS. Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 1990;39(11):1315-1319.

II. Quinn LM, Wong FS, Narendran P. Environmental determinants of type 1 diabetes: from association to proving causality. Front Immunol 2021. doi: 10.3389/fimmu.2021.737964.

III. Isaacs SR, Roy A, Dance B, et al. Enteroviruses and risk of islet autoimmunity or type 1 diabetes: systematic review and meta-analysis of controlled observational studies detecting viral nucleic acids and proteins. Lancet Diab Endocrinol 2023;11(8):578-592.

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Published

2025-10-27

Issue

Vol. 59 No. 3 (2025): September-December 2025

Section

Editorial

License

Copyright (c) 2025 on behalf of the authors. Reproduction rights: Argentine Society of Diabetes

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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