Relation between diabetes oxidative stress and periodontal disease
DOI:
https://doi.org/10.47196/diab.v48i2.208Keywords:
diabetes, periodontal disease, oxidative stressAbstract
Introduction: the diabetic mellitus comprises a heterogeneous disorder characterize by hiperglycemia and impaired lipid and carbohydrate metabolism. The diabetic disease it is associated with a number of complications, resulting directly from hyperglycemia. Between others periodontal disease is very important complication of diabetes. Oxidatve stress plays an important role in the pathogenesis of periodontal disease. Material and methods: wistar male rats were injected with STZ (65 mg/kg). At the end of 4th weeks gingival and blood were obtained to biochemical determinations. Oxidative changes were determined by glutathione activity (GSH), lipid peroxidase (MDA) , nitric oxide (NO) and glycemias.
Results: STZ treatment produced significant changes in glycemias, plasma and gingival tissue MDA and NO compared to control. The antioxidant activity GSH was significant reduced in plasma and gingival tissue respect to controls.
Conclusion: the diabetes affects all oxidant and antioxidant parameters in plasma and gingival tissue decreasing the defense capacity and causing damage to periodontal tissue.
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