Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia

Authors

  • Marina Inés Curriá British Hospital, Autonomous City of Buenos Aires, Argentina
  • María Jimena Cerar British Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Gabriela Rovira British Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Melina Saban British Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Glenda Ernst British Hospital, Autonomous City of Buenos Aires, Argentina
  • Adriana L. Burgueño Argentine Catholic University (UCA), Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v56i2.515

Keywords:

free fatty acids, pregnancy, macrosomia

Abstract

Introduction: neonates with high birth weight are at increased risk of birth complications and long term health problems. An unexplored factor during gestation is the level of circulating fatty acids.
Materials and methods: prospective study where women were studied during pregnancy until delivery. Anthropometric variables and free fatty acid measurements were analyzed between 24-28 weeks of gestation.
Results: we included 27 patients, of whom 4 (13.8%) gave birth to macrosomic newborns. Patients were grouped according to pre- regnancy mass index (BMI) into normal weight and overweight or obese. Macrosomic neonates corresponded to the group of overweight and obese mothers, who also presented a significant increase in free fatty acid levels (2067 uM, ICC: 947,5-1590 vs 1212 uM, ICC: 13367-2247; p<0.05) was found in the obese and overweight group. Basal and post oral glucose tolerance test showed no differences, Multivariate analysis showed that being obese or overweight at the beginning of pregnancy results in an OR of free fatty acids 1,0023 (95%CI: 1,0000-1,0046), while oral glucose tolerance test presented an OR: 1,0186 (95%CI: 0,9645-1,0756).
Conclusions: the results show the role of pre-gestational BMI on the risk of having macrosomic children, confirming the need to improve the nutritional status of women before and during pregnancy

Author Biographies

Marina Inés Curriá, British Hospital, Autonomous City of Buenos Aires, Argentina

University Doctor, Endocrinologist; Head of the Endocrinology, Metabolism, Nutrition and Diabetes Service

María Jimena Cerar, British Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Tocogynecologist, Obstetrics Service

Gabriela Rovira, British Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Endocrinologist; Staff of the Department of Endocrinology, Metabolism, Nutrition and Diabetes

Melina Saban, British Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Endocrinologist; Staff of the Endocrinology, Metabolism, Nutrition and Diabetes Service; Scientific Advisory Committee

Glenda Ernst, British Hospital, Autonomous City of Buenos Aires, Argentina

University Doctor, Pulmonology Service, Scientific Advisory Committee

Adriana L. Burgueño, Argentine Catholic University (UCA), Autonomous City of Buenos Aires, Argentina

University Doctor, Psychoneuroendocrinoimmunology Laboratory, Biomedical Research Institute (BIOMED), National Council for Scientific and Technical Research (CONICET)

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Published

2022-08-01

How to Cite

Curriá, M. I., Cerar, M. J., Rovira, G., Saban, M., Ernst, G., & Burgueño, A. L. (2022). Relationship between body mass index and maternal circulating fatty acid levels as predictors of the presence of fetal macrosomia. Journal of the Argentine Society of Diabetes, 56(2), 57–62. https://doi.org/10.47196/diab.v56i2.515

Issue

Vol. 56 No. 2 (2022): May/Agost 2022

Section

Original article

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