Symposium 9: Diabetes and the liver: beyond glycemia
DOI:
https://doi.org/10.47196/diab.v54i3Sup.306Keywords:
liver, diseasesAbstract
Symposium 9: Hepatic involvement in diabetes: beyond the liver
Diabetes and the liver: beyond glycemia
Non-alcoholic fatty liver disease (NAFLD) represents the hepatic response to the insult of an altered systemic metabolism. In South America, a 25% of the “healthy” individuals have NAFLD, mainly simple steatosis (SS), and a 20% of this figure can progress to non alcoholic steatosis hepatitis (NASH), which means there is presence of hepatocyte ballooning and inflammation. It is even more important that a 20% of the patients with NASH can progress to fibrosis, or even to cirrhosis. For years, SS has been considered a “benign” disease; although said paradigm is being tested since monitoring of patients with serial biopsies revealed that up to a 25% of the patients with SS progressed to fibrosis. Why is it important to identify patients with fibrosis? Because fibrosis is directly associated with higher mortality.
References
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- Atorrasagasti C, Onorato A, Gimeno ML, Andreone L, García M, Malvicini M, Fiore E, Bayo J, Perone MJ, Mazzolini GD. SPARC is required for the maintenance of glucose homeostasis and insulin secretion in mice. Clinical Science 2019; 133(2):351–365. https://doi.org/10.1042/CS20180714
- Mazzolini G, Atorrasagasti C, Onorato A, Peixoto E, Schlattjan M, Sowa JP, Sydor S, Gerken G, Canbay A. SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease. Sci Rep 2018; 8(1): 725. https://doi.org/10.1038/s41598-017-18981-9.
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