Plenary conference: Auto, alo and islet xenotransplantation

Authors

  • Rita Bottino Allegheny Health Network, Imagine Pharma Pittsburgh, Pensilvania, Estados Unidos

DOI:

https://doi.org/10.47196/diab.v54i3Sup.309

Keywords:

islet transplantation, diabetes

Abstract

Plenary conference: Auto, alo and islet xenotransplantation

Islet transplantation is a cell therapeutic approach finalized to improve glycemic control in patients that have lost beta cells to autoimmune destruction (as in type 1 diabetes) or due to surgical excision of the pancreas (typically for severe, untreatable chronic pancreatitis). 

Autologous islet transplantation entails the isolation of pancreatic islets from one patient undergoing total pancreatectomy and intraportal infusion of the islets to the same patient in order to maintain endogenous production of insulin in the absence of immune rejection. This is a clinically viable procedure that successfully allows at least 60% of islet autotransplantation recipients to control glycemias often enjoying years of insulin independence.

Author Biography

Rita Bottino, Allegheny Health Network, Imagine Pharma Pittsburgh, Pensilvania, Estados Unidos

Associate Professor

References

-1- JACS 2012;214:409-26

-2- JCEM 2015;100:1765-70-395

-3- Diabetes Care, 35:436-45, 2012

-4- Diabetes Care. 2016 Jul;39(7):1230-40

-5- Science. 2003 January 17; 299(5605): 411-414.

-6- Xenotransplantation. 2020; 27(3): e12621.

Published

2023-01-10

How to Cite

Bottino, R. (2023). Plenary conference: Auto, alo and islet xenotransplantation. Journal of the Argentine Society of Diabetes, 54(3Sup), 41–41. https://doi.org/10.47196/diab.v54i3Sup.309

Issue

Section

Conferencia Plenaria Parte 2