Symposium 10: Adipose tissue

Authors

  • Solange Houssay Associated Hospital Dr. José María Ramos Mejía, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i3Sup.312

Keywords:

adipose tissue, diabetes

Abstract

Symposium 10: Insulin resistance: from pathophysiology to treatment

Adipose tissue

The adipocyte uptakes the glucose stimulated by the insulin, and this function becomes resistant in obesity and type 2 diabetes (T2D). However, the adipose tissue (AT) is not a meaningful place of quantity of glucose stimulated by insulin attraction. It represents a 5% of the oral glucose load in humans.

In spite of this, the organ-specific GLUT-4 deletion in the AT of mice shows as a result insulin resistance in the liver and the skeletal muscle that aims to indirect and physiologically meaningful effects as a consequence of the insulin resistance in the uptake of glucose in the AT.

Author Biography

Solange Houssay, Associated Hospital Dr. José María Ramos Mejía, Autonomous City of Buenos Aires, Argentina

Doctor, specialist in Diabetes and Nutrition

References

- Schwartz SS, Epstein S, Corkey BE, et al. The time is right for a New Classification System for Diabetes: Rationale and Implications of the B-Cell-Centric Classification Schema. Diabetes Care 2016;39:179-186.

- Shulman GI. Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease. N Engl J Med 2014;371:1131-41.

- Petersen MC, Shulman GI. Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev 2018; 98:2133-2223.

- Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. The Journal of Clinical Investigation. 2011;121(6):2111-2117.

- Archer E, Lavie CJ, Hill JO. The Contributions of “Diet”, “Genes” and Physical Activity to the Etiology of Obesity: Contrary Evidence and Consilience Progress in Cardiovascular Diseases 2018; 61(2):89-102.

Published

2023-01-10

How to Cite

Houssay, S. (2023). Symposium 10: Adipose tissue. Journal of the Argentine Society of Diabetes, 54(3Sup), 43–43. https://doi.org/10.47196/diab.v54i3Sup.312

Similar Articles

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>