O11 Less amount of hours a week of physical activity is associated to alterations of glucose metabolism in children and adolescents from Mendoza, Argentina

Abstract

Introduction: Sedentism has emerged as an independent risk factor within the pediatric population. It is associated to metabolic syndrome, the alteration of body composition and the decrease of academic performance, but its relationship with glycemic alterations has not been yet clarified.

Objectives: Evaluate the relationship between the amount of hours a week of physical activity and the alterations in glucose metabolism in obese children and adolescents.

Materials and Methods: A total of 78 obese patients were studied and separated in quartiles of programmed and spontaneous physical activity. What was obtained was a BMI z-score, waist/size, blood pressure (SBP and DBP), fat mass and lean mass by densitometry, adiponectin, myostatin, fasting metabolic parameters (glycemia, HOMAIR) and, during OGTT: area under the curve (AUC), whole body insulin sensitivity (Matsuda) and muscle and hepatic insulin sensitivity (DeFronzo), glucose disposition index (GDI) and AGA, ITG and diabetes frequency. Student’s t and ANOVA were used with a logarithmic transformation, Chi-square and Odd Ratios to compare groups, frequencies and probability of metabolic alterations.

Conclusions: obese patients who develop less than 8 hours of programmed and spontaneous weekly activity have lower levels of adiponectin, increased of myostatin, decreased muscle sensitivity to insulin and a greater likelihood of developing alterations in carbohydrate metabolism and diabetes.