P6 Effect of platelet-rich xenogenic gel on induced skin ulcer healing in a rat model with type 2 diabetes

Abstract

Introduction: skin ulcers can generate serious complications in people with diabetes, which can lead to partial or total amputation of the compromised limb. Platelet-rich gel is being used frequently to promote the healing of a skin ulcer. However, the clinical outcomes in healing are often variable because the factors that influence this procedure are not yet fully understood.

Objective: to evaluate the effect of the platelet-rich xenogenic gel on the healing of an induced skin ulcer in a model in rats with type 2 diabetes (T2D).

Materials and methods: 12 Sprague dawley rats were used and divided into 3 groups of 4 rats with an induced 15mm skin ulcer each. Group 1 (with T2D): platelet-rich xenogenic gel was applied. Group 2 (rats with T2D) and group 3 (rats without T2D) applied saline and a dressing. The wound surface was measured on days 0, 20, 29 and 33 using a digital micrometer and photographs.

Results: Significant differences were found between pre and post treatment wounds in the group of diabetics with platelet-rich gel (1.25 ± 2.5 mm) compared to standard care (7.96 ± 2.7 mm), (p <0.05). No serious adverse events related to treatment were reported.

Conclusions: the gel rich in platelets of human origin showed beneficial effects on the healing of the induced ulcers in rats with type 2 diabetes, and did not generate any adverse effect in the treated animals, supporting the use of the gel rich in platelets even in xenogenic form.