P51 Chronic complications of diabetes and vitamin D, a forgotten factor

Abstract

Introduction: In recent years there has been an exponential increase in diabetic patients. During the course of the disease, many of these patients will develop various chronic complications that tend to increase morbidity and mortality with significantbiopsychosocial repercussions associated with the highest in healthcare spending. (1-4)In order to prevent these complications, good glycemic-metabolic, and associated cardiovascular risk factors controls are essential. (5) However, although having an adequate control of the factors mentioned before, many patients continue presenting different chronic complications. This raises the suspicion of theexistence of other associated factors, one of them being vitamin D deficiency, which is observed with increasing prevalence in diabetic patients (6) and which could be a changeable risk factor linked to the development and progression of chronic complications of diabetes.Objectives: Estimate the prevalence of chronic complications of diabetes and hypovitaminosis D.Determine the association between vitamin D deficiency and chronic complications of diabetes.

Materials and methods: A retrospective study was carried out by the team from the Nutrition section. It was used the computerized medical history to collect data on chronic complications of diabetes and 25OHD levels from the population. The association between chronic complications and vitamin D deficiency was analyzed.

Results: 252 patients were analyzed. Median age is 70 years, 52% male, with a predominance of type 2 diabetics (91.67%), a median evolution of the disease of 9 years, and a median HbA1c of 6.7%. 60% of the patients present chronic complications of the disease and 71% with hypovitaminosis D, being 38% with deficiency levels (25OHD <20 ng / ml). In the multivariate analysis, vitamin D deficiency was significantly associated with chronic complications of diabetes (p <0.001; OR 5.08) regardless of age, diabetes progression, HbA1c, dyslipidemia, obesity, hypertension, and smoking.

Conclusions: There is a high prevalence of chronic complications of diabetes and hypovitaminosis D in patients. A strong association was observed between vitamin D deficiency and chronic complications of diabetes, regardless of glycemic control and conventional cardiovascularrisk factors.