Symposium 3: HbA1c: Are HbA1c determinations reliable enough today in Argentina to adopt them as diagnostic criteria?
DOI:
https://doi.org/10.47196/diab.v56i3Sup.495Keywords:
HbA1c, diabetes mellitusAbstract
The standardization and efforts in the harmonization of the analytical process of Glycated Hemoglobin (HbA1c), its low biological variability, the possibility of performing the test without fasting, among others1, led the American Diabetes Association (ADA) to recommend HbA1c for the detection and diagnosis of diabetes in 2010. Similar recommendations were endorsed by the IDF and WHO2.
Currently few methods show interference by one or more of the most common heterozygous hemoglobin variants. Others, such as ion exchange HPLC and capillary electrophoresis, detect them and alert about their presence. Rare hemoglobin variants may interfere with tests for HbA1c, which is specific to the method used.
References
I. Sacks DB. A1C versus glucose testing: a comparison. Diabetes Care 2011;518-23.
II. Little RR, Rohlfing C, Sacks DB. The NGSP: over 20 years of improving HbA1c measurement. Clin Chem 2019 July;65(7):839-848.
III. Convergencias, divergencias, variabilidad, puntos de corte e indicación de la glucemia de ayuno, la hemoglobina glucosilada e insulinemia. Jornadas Rioplatenses, 24 y 25 de abril de 2010. Colonia, República Oriental del Uruguay.
IV. Guía de Práctica Clínica Nacional sobre Prevención, Diagnóstico y Tratamiento de la Diabetes Mellitus Tipo 2 (DM2) 2019. Disponible en: https://bancos.salud.gob.ar/sites/default/files/2020-09/guia-nacional-practica-clinica-diabetes-mellitius-tipo2_2019.pdf.
V. NGSP. HbA1c Assay Interferences. Disponible en: www.ngsp.org/interf.asp.
VI. Fuente: ProgBA.
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