Symposium 11: Obesity as beta cell stressor at the start

Abstract

The accelerator hypothesis, which proposes a link between type 1 diabetes (T1D) and type 2 diabetes (T2D) through insulin resistance and related to body weight. The prevalence of the two most common forms of diabetes, type 1 (T1D) and type 2 (T2D) is increasing worldwide, including in the pediatric population, rapidly becoming an urgent public health problem. The International Diabetes Federation has estimated that T1D affects more than 1,100,000 children and adolescents, with an annual incidence of about 128,900 worldwide, as well as the increase in the prevalence of type 2 diabetes in children gives an estimate of fourfold to the current one for the United States, in the year 2050. In addition, prediabetes affects almost 5% of children between the ages of 6 and 10 years.

The study of the impact of onset diabetes in childhood and adolescence showed that hyperglycemia is not the only cardiovascular risk factor, others being glycemic variability, hypoglycemia, obesity, insulin resistance, waist circumference. The obesity pandemic does not leave children out.