Pregnancy Committee. Importance of postpartum reclassification in gestational diabetes mellitus
DOI:
https://doi.org/10.47196/diab.v58i1Sup.757Keywords:
gestational diabetes mellitus, reclassification, type 2 diabetes mellitus, cardiovascular diseaseAbstract
The physiological adaptation of different systems, the hormonal modifications in each trimester, with the insulin resistance typical of the third, favor the appearance of gestational diabetes and other pathologies during pregnancy. Approximately 10% of pregnant women in our country develop gestational diabetes.
Pregnancy is a state of hyperinsulinemia with insulin resistance, which can generate an increase in inflammatory markers. Subclinical atherosclerosis is observed during pregnancies with GDM, especially in patients with BMI >25, and it is a risk factor for future CV events. In the future, after childbirth, anincresed probability of developing diabetes mellitus, obesity, dyslipidemia, hypertension and cardiovascular disease is described, independent of the development of type 2 diabetes.It seems that the increase in the carotid intima thickness appeared before pregnancy.
We must also consider that there is a group of women who develop diabetes during pregnancy, both type 1 and type 2 or other types of diabetes. There are also women with pregestational diabetes who do not know their condition, which is diagnosed during pregnancy.
For the mother, the diagnosis of gestational diabetes increases the risk of pregnancy-induced hypertension,preeclampsia and eclampsia, as well as the presence of hypertriglyceridemia. They also present a higher risk of cesarean section and preterm birth. The increase in the prevalence of obesity in women of childbearing age, as well as the increase in the age of pregnant women, are factors that are strongly associated with the increase in the pathologies described.
The inflammatory processes involved include the increase in C-reactive protein and other cytokines. Breastfeeding is associated with a decreased risk of developing type 2 diabetes and hypertension.
Therefore, timely reclassification at six weeks postpartum will allow us to evaluate not only carbohydrate and lipid metabolism, but also the risks of developing type 2 diabetes and cardiovascular complications and is a great opportunity to intervene early, to reduce these risks.
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