Mesa 2: Insuficiencia cardíaca y diabetes mellitus tipo 2

Autores/as

  • Julieta Méndez Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina
  • Carolina Gómez Martín Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina
  • Javier Remón Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina
  • Solange Houssay Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina
  • Ezequiel Forte Sociedad Argentina de Cardiología, Centro de Diagnóstico Cardiovascular (CENDIC), Concordia, Entre Ríos, Argentina
  • Silvana Manfredo Sociedad Argentina de Diabetes, Clínica Privada de Diabetes, Necochea, Provincia de Buenos Aires, Argentina
  • María Laura Roselli Sociedad Argentina de Diabetes, personal del Hospital Municipal Esteban Iribarne, Suipacha, Provincia de Buenos Aires, Argentina
  • Matías Re Sociedad Argentina de Diabetes, Hospital San Juan de Dios, Centro de Diagnóstico, Tratamiento y Educación de Diabetes y Factores de Riesgo Cardiovascular (CEDIAB), La Plata, Provincia de Buenos Aires, Argentina
  • Débora Hernández Sociedad Argentina de Diabetes, Hospital General de Agudos Dr. Parmenio Piñero, Ciudad Autónoma de Buenos Aires, Hospital Universitario Austral, Pilar, Provincia de Buenos Aires, Argentina
  • Marina Margosian Sociedad Argentina de Diabetes, Especialista en Nutrición y Diabetes, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires (UBA), Ciudad Autónoma de Buenos Aires, Argentina
  • Melina Sabán Sociedad Argentina de Diabetes, Hospital Británico, Ciudad Autónoma de Buenos Aires, Argentina
  • Martín Maraschio Sociedad Argentina de Diabetes, Hospital Municipal Dr. A. Pintos, Azul, Provincia de Buenos Aires, Argentina
  • Natalia Blanco Sociedad Argentina de Diabetes, Hospital Escuela de Agudos, Dr. Ramón Madariaga, Posadas, Misiones, Argentina
  • Rubén de Marco Sociedad Argentina de Diabetes, Hospital El Cruce-Dr. Néstor Kirchner, Florencio Varela, Provincia de Buenos Aires, Argentina
  • Sandra Salva Sociedad Argentina de Diabetes. Hospital Zonal General de Agudos Dr. Alberto Edgardo Balestrini, Ciudad Evita, Provincia de Buenos Aires. Hospital Italiano Centro Agustín Roca, San Justo, Provincia de Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i2Sup.252

Palabras clave:

insuficiencia cardíaca, diabetes, riesgo cardiovascular, enfermedad coronaria, fracción de eyección

Resumen

Desde que el estudio Framingham en 1974 reportó un aumento de dos a cinco veces en el riesgo de desarrollar insuficiencia cardíaca (IC) en pacientes con diabetes mellitus (DM), otros estudios observacionales confirmaron esta asociación que ha tomado gran visibilidad en los últimos años a partir de los resultados de los estudios de seguridad cardiovascular de las drogas antidiabéticas.

La IC se define como un síndrome clínico que resulta del deterioro funcional o estructural del llenado ventricular o la eyección de sangre. Puede clasificarse según la fracción de eyección, la presencia de síntomas y la limitación de la actividad física.

Existen distintos factores asociados a la IC en personas con DM como la edad, la antigüedad de la enfermedad, la utilización de insulina, la enfermedad coronaria, la hipertensión arterial, la enfermedad arterial periférica, el aumento de creatinina, el escaso control glucémico, la albuminuria y la obesidad. A su vez la IC se asocia a insulinorresistencia y a estados disglucémicos que se consideran de riesgo para el desarrollo de DM.

Biografía del autor/a

Julieta Méndez, Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina

Médica; Coordinadora del Programa Nacional de Prevención y Control de Personas con Diabetes Mellitus

Carolina Gómez Martín, Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Miembro del Comité de Hipertensión Arterial y Factores de Riesgo Cardiovascular, Sociedad Argentina de Diabetes; Médica especializada en Diabetes; Co-Directora Centro Integral de Endocrinología y Diabetes (CENDIA)

Javier Remón, Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médico de Planta, Servicio Nutrición y Diabetes, Hospital Privado de Comunidad

Solange Houssay, Sociedad Argentina de Diabetes, Ciudad Autónoma de Buenos Aires, Argentina

Coordinadora del Comité de Hipertensión Arterial y Factores de Riesgo Cardiovascular, Sociedad Argentina de Diabetes; Médica de Planta, Unidad Nutrición, Hospital General de Agudos Dr. José María Ramos Mejía

Ezequiel Forte, Sociedad Argentina de Cardiología, Centro de Diagnóstico Cardiovascular (CENDIC), Concordia, Entre Ríos, Argentina

Consejo de Cardiometabolismo, Sociedad Argentina de Cardiología; Médico Cardiólogo; Director Médico de Centro de Diagnóstico Cardiovascular (CENDIC)

Silvana Manfredo, Sociedad Argentina de Diabetes, Clínica Privada de Diabetes, Necochea, Provincia de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médica Diabetóloga, Consultorio Privado de Diabetología

María Laura Roselli, Sociedad Argentina de Diabetes, personal del Hospital Municipal Esteban Iribarne, Suipacha, Provincia de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médica, staff Hospital Municipal Esteban Iribarne

Matías Re, Sociedad Argentina de Diabetes, Hospital San Juan de Dios, Centro de Diagnóstico, Tratamiento y Educación de Diabetes y Factores de Riesgo Cardiovascular (CEDIAB), La Plata, Provincia de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médico; Jefe unidad de Diabetes, Hospital San Juan de Dios; Médico clínico especializado en diabetes, Centro de Diagnóstico, Tratamiento y Educación en Diabetes y Factores de Riesgo Cardiovascular (CEDIAB)

Débora Hernández, Sociedad Argentina de Diabetes, Hospital General de Agudos Dr. Parmenio Piñero, Ciudad Autónoma de Buenos Aires, Hospital Universitario Austral, Pilar, Provincia de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médica, Servicio Clínica Médica, Hospital General de Agudos Dr. Parmenio Piñero; Médica, staff del Servicio de Diabetología, Hospital Universitario Austral

Marina Margosian, Sociedad Argentina de Diabetes, Especialista en Nutrición y Diabetes, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires (UBA), Ciudad Autónoma de Buenos Aires, Argentina

Miembro del Comité de Hipertensión Arterial y Factores de Riesgo Cardiovascular, Sociedad Argentina de Diabetes; Médica especialista en Nutrición y Diabetes, División Diabetes del Hospital de Clínicas José de San Martín

Melina Sabán, Sociedad Argentina de Diabetes, Hospital Británico, Ciudad Autónoma de Buenos Aires, Argentina

Miembro del Comité de Hipertensión Arterial y Factores de Riesgo Cardiovascular, Sociedad Argentina de Diabetes; Médica, staff del Servicio de Endocrinología, Metabolismo, Nutrición y Diabetes, Hospital Británico

Martín Maraschio, Sociedad Argentina de Diabetes, Hospital Municipal Dr. A. Pintos, Azul, Provincia de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médico Diabetólogo; Jefe del Servicio de Clínica Médica Hospital Municipal Dr. A. Pintos

Natalia Blanco, Sociedad Argentina de Diabetes, Hospital Escuela de Agudos, Dr. Ramón Madariaga, Posadas, Misiones, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médica Diabetóloga, Hospital Escuela de Agudos, Dr. Ramón Madariaga

Rubén de Marco, Sociedad Argentina de Diabetes, Hospital El Cruce-Dr. Néstor Kirchner, Florencio Varela, Provincia de Buenos Aires, Argentina

Miembro del Comité de Graduados, Sociedad Argentina de Diabetes; Médico Diabetólogo; Coordinador de la Unidad de Diabetes, Hospital El Cruce-Dr. Néstor Kirchner

Sandra Salva, Sociedad Argentina de Diabetes. Hospital Zonal General de Agudos Dr. Alberto Edgardo Balestrini, Ciudad Evita, Provincia de Buenos Aires. Hospital Italiano Centro Agustín Roca, San Justo, Provincia de Buenos Aires, Argentina

Miembro del Comité de Hipertensión Arterial y Factores de Riesgo Cardiovascular, Sociedad Argentina de Diabetes; Médica del Servicio Clínica Médica, Sección Nutrición y Diabetes, Hospital Zonal General de Agudos Dr. Alberto Edgardo Balestrini; Médica asociada a Clínica Médica, Hospital Italiano Centro Agustín Roca

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LXXX. Bell DSH, Goncalves E. Heart failure in the patient with diabetes: epidemiology, aetiology, prognosis, therapy and the effect of glucose-lowering medications. Diabetes Obes Metab 2019 Jun; 21(6):1277-90.

LXXXI. Davie AP, Francis CM, Love MP, Caruana L, Starkey IR, Shaw TR, Sutherland GR, McMurray JJ. Value of the electrocardiogram in identifying heart failure due to left ventricular systolic dysfunction. BMJ 1996 Jan 27; 312(7025):222.

LXXXII. Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbély A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J 2007 Oct; 28(20):2539-50.

LXXXIII. Pennell DJ, Sechtem UP, Higgins CB, Manning WJ, Pohost GM, Rademakers FE, van Rossum AC, Shaw LJ, Yucel EK, European Society of cardiology, Society for Cardiovascular Magnetic Resonance. Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report. J Cardiovasc Magn Reson 2004; 6(4):727-65.

LXXXIV. Hendel RC, Patel MR, Kramer CM, Poon M, Hendel RC, Carr JC, Gerstad NA, Gillam LD, Hodgson JM, Kim RJ, Kramer CM, Lesser JR, Martin ET, Messer JV, Redberg RF, Rubin GD, Rumsfeld JS, Taylor AJ, Weigold WG, Woodard PK, Brindis RG, Hendel RC, Douglas PS, Peterson ED, Wolk MJ, Allen JM, Patel MR; American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology. ACCF/ACR/SCCT/SCMR/ASNC/NASCI/SCAI/SIR 2006 appropriateness criteria for cardiac computed tomography and cardiac magnetic resonance imaging: a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group, American College of Radiology, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, American Society of Nuclear Cardiology, North American Society for Cardiac Imaging, Society for Cardiovascular Angiography and Interventions, and Society of Interventional Radiology. J Am Coll Cardiol 2006 Oct 3; 48(7):1475-97.

LXXXV. Gerstein HC, Miller ME, Byington RP, Goff DC Jr, Bigger JT, Buse JB, Cushman WC, Genuth S, Ismail-Beigi F, Grimm RH Jr, Probstfield JL, Simons-Morton DG, Friedewald WT; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008 Jun 12; 358(24):2545-59.

LXXXVI. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F; ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008 Jun 12; 358(24):2560-72.

LXXXVII. Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, Zieve FJ, Marks J, Davis SN, Hayward R, Warren SR, Goldman S, McCarren M, Vitek ME, Henderson WG, Huang GD; VADT Investigators. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009 Jan 8; 360(2):129-39.

LXXXVIII. Frye RL, August P, Brooks MM, Hardison RM, Kelsey SF, MacGregor JM, Orchard TJ, Chaitman BR, Genuth SM, Goldberg SH, Hlatky MA, Jones TLZ, Molitch ME, Nesto RW, Sako EY, Sobel BE; BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med 2009 Jun 11; 360(24):2503-15.

LXXXIX. Gerstein HC, Bosch J, Dagenais GR, Díaz R, Jung H, Maggioni AP, Pogue J, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, Yusuf S; ORIGIN Trial Investigators. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 2012 Jul 26; 367(4):319-28.

XC. Gerstein HC, Jung H, Rydén L, Diaz R, Gilbert RE, Yusuf S; ORIGIN Investigators. Effect of basal insulin glargine on first and recurrent episodes of heart failure hospitalization: The ORIGIN Trial (Outcome Reduction With Initial Glargine Intervention). Circulation 2018 Jan 2; 137(1):88-90.

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XCII. Home PD, Pocock SJ, Beck-Nielsen H, Curtis PS, Gomis R, Hanefeld M, Jones NP, Komajda M, McMurray JJV. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. The Lancet 2009; 373: 2125-35. Disponible en: http://dx.doi.org/10.1016/s0140-6736(09)60953-3.

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XCIV. Scirica BM, Bhatt DL, Braunwald E, Gabriel Steg P, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I. Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. New England Journal of Medicine 2013; 369: 1317-26. Disponible en: http://dx.doi.org/10.1056/nejmoa1307684.

XCV. White WB, Bakris GL, Bergenstal RM, Cannon CP, Cushman WC, Fleck P, Heller S, Mehta C, Nissen SE, Perez A, Wilson C, Zannad F. Examination of cardiovascular outcomes with alogliptIn vs standard of care in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE). American Heart Journal 2011; 162:620-6.e1. Disponible en: http://dx.doi.org/10.1016/j.ahj.2011.08.004.

XCVI. Green JB, Angelyn-Bethel M, Armstrong PW, Buse JB, Engel SS, Garg J, Josse R, Kaufman KD, Koglin J, Korn S, Lachin JM, McGuire DK, Pencina MJ, Standl E, Stein PP, Suryawanshi S, Van de Werf F, Peterson ED, Holman RR. Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes. New England Journal of Medicine 2015; 373:232-42. Disponible en: http://dx.doi.org/10.1056/nejmoa1501352.

XCVII. McGuire DK, Alexander JH, Johansen OE, Perkovic V, Rosenstock J, Cooper ME, Wanner C, Kahn SE, Toto RD, Zinman B, Baanstra D, Pfarr E, Schnaidt S, Meinicke T, George JT, von Eynatten M, Marx N; on behalf of the CARMELINA Investigators. Linagliptin effects on heart failure and related outcomes in individuals with type 2 diabetes mellitus at high cardiovascular and renal risk in CARMELINA. Circulation 2019; 139:351-61. Disponible en: http://dx.doi.org/10.1161/circulationaha.118.038352.

XCVIII. Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB. Liraglutide and cardiovascular outcomes in type 2 diabetes. New England Journal of Medicine 2016; 375:311-22. Disponible en: http://dx.doi.org/10.1056/nejmoa1603827.

XCIX. Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jódar E, Leiter LA, Lingvay I, Rosenstock J, Seufert J, Warren ML, Woo V, Hansen O, Holst AG, Pettersson J, Vilsbøll T. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. New England Journal of Medicine 2016; 375:1834-44. Disponible en: http://dx.doi.org/10.1056/nejmoa1607141.

C. Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Køber LV, Lawson FC, Ping L, Wei X, Lewis EF, Maggioni AP, McMurray JJV, Probstfield JL, Riddle MC, Solomon SD, Tardif J-C. Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. New England Journal of Medicine 2015; 373:2247-57. Disponible en: http://dx.doi.org/10.1056/nejmoa1509225.

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CII. Eurich DT, Weir DL, Majumdar SR, Tsuyuki RT, Johnson JA, Tjosvold L, Vanderloo SE, McAlister FA. Comparative safety and effectiveness of metformin in patients with diabetes mellitus and heart failure: systematic review of observational studies involving 34,000 patients. Circ Heart Fail 2013 May; 6(3):395-402.

CIII. Yang D-Y, He X, Liang H-W, Zhang S-Z, Zhong X-B, Luo C-F, Du Z-M, He J-G, Zhuang X-D, Liao X-X. Comparative outcomes of heart failure among existent classes of anti-diabetic agents: a network meta-analysis of 171.253 participants from 91 randomized controlled trials. Cardiovasc Diabetol 2019 Apr 8; 18(1):47.

CIV. Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, Mattheus M, Devins T, Johansen OE, Woerle HJ, Broedl UC, Inzucchi SE; EMPA-REG OUTCOME Investigators. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015 Nov 26; 373(22):2117-28.

CV. Neal B, Perkovic V, Mahaffey KW, de Zeeuw D, Fulcher G, Erondu N, Shaw W, Law G, Desai M, Matthews DR. Canagliflozin and cardiovascular and renal events in type 2 diabetes. New England Journal of Medicine 2017; 377:644-57. Disponible en: http://dx.doi.org/10.1056/nejmoa1611925.

CVI. Wiviott SD, Raz I, Bonaca MP, Mosenzon O, Kato ET, Cahn A, Silverman MG, Zelniker TA, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Ruff CT, Gause-Nilsson IAM, Fredriksson M, Johansson PA, Langkilde A-M, Sabatine MS; DECLARE–TIMI 58 Investigators. Dapagliflozin and cardiovascular outcomes in type 2 diabetes. N Engl J Med 2019 Jan 24; 380(4):347-57.

CVII. Tentolouris A, Vlachakis P, Tzeravini E, Eleftheriadou I, Tentolouris N. SGLT-2 inhibitors: a review of their antidiabetic and cardioprotective effects. Int J Environ Res Public Health 2019 Aug 17; 16(16):2965.

CVIII. Bowes CD, Lien LF, Butler J. Clinical aspects of heart failure in individuals with diabetes. Diabetologia 2019 Sep; 62(9):1529-38.

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10-01-2023

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Méndez, J., Gómez Martín, C., Remón, J., Houssay, S., Forte, E., Manfredo, S., Roselli, M. L., Re, M., Hernández, D., Margosian, M., Sabán, M., Maraschio, M., Blanco, N., de Marco, R., & Salva, S. (2023). Mesa 2: Insuficiencia cardíaca y diabetes mellitus tipo 2. Revista De La Sociedad Argentina De Diabetes, 54(2Sup), 91–106. https://doi.org/10.47196/diab.v54i2Sup.252

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