O12 Early-onset obesity is associated to birth weight, sedentary habits and the components of the pediatric metabolic syndrome

Abstract

Introduction: Obesity complications appear early in children. Their frequency varies with the severity of the body fat accumulation and its distribution. Birth weight (BW), the early onset of diabetes and sedentism could aggravate metabolic risk.

Objectives: Determining the factors that are related to obesity severity and the presence of the components of the pediatric metabolic syndrome.

Materials and Methods: A total of 78 patients were studied between 5-15 years old and with variable degrees of overweight. It was obtained: BW, Physical activity sore (Godard scale), BMI z-score, waist and size circumference, percentile, blood pressure (SBP and DBP), fat mass and lean mass by densitometry, glycemia, lipids, transaminases, PCR, insulinemia, C-Peptide, HOMA-Adiponectin, whole body insulin sensitivity (Matsuda) and muscle insulin sensitivity (DeFronzo), with the glucose tolerance test. ANOVA, Chisquare and Mann-Whitney test were used to compare groups, frequencies and nonnormal variables.

Results: patients with severe obesity had a higher BW, onset of overweight before the age of 5 years and a greater number of sedentary hours, associated with a trunk fat disposition, alteration of the lipid profile, blood pressure, GPT/GOT ratio and increased CRP. without differences in glycemia. The adiponectin HOMA index, insulinemia and C-peptide at 120 minutes were higher, and muscle sensitivity to insulin was lower in the total obese group.

Conclusions: Early onset severe obesity is associated to inflammation markers, truncal and ectopic fat accumulation with lower muscle insulin sensitivity. It sets a predisposition for pediatric metabolic syndrome.