P24 Hypoglycemia: prevalence and characterization in adult patients with type 1 and type 2 diabetes in the Comahue region

Abstract

Introduction: hypoglycemia is a common adverse effect of diabetes treatment and is considered the major limiting factor in treatment. Addressing this issue is very important both in the office and in research.

Objectives: Asses the prevalence of any hypoglycemic event in adult patients with diabetes in the Comahue region and characterize them according to severity level (1,2y3) -D escribe the relationship between the prevalence of any event of the different hypoglycemic levels with sex, age, hbA1c, type of diabetes, duration of diabetes (years), type of treatment and complications associated with diabetes.

Materials and methods: Observational, multicenter, cross-sectional study, carried out between May and July 2020 in the Comahue Chapter of SAD. Patients with diabetes diagnosis aged >18 years were randomly surveyed.

Results: 452 patients answered the questionnaire (T1D: 18.1% and T2D: 78.8%). Mean age: 53.8 years Sex: male 51.1%. The mean duration of diabetes was 11.16 years. The mean HbA1c was 7.75%. The prevalence of any hypoglycemic event was 41%. In T1D it was 85.3% and 30.6% in T2D. In patients with T1D the prevalence for non-severe hypoglycemia, level 1, level 2, severe and nocturnal hypoglycemia was 82.9%, 80.4%, 31.7%, 23.1% and 51.2% respectively. Patients with T2D had a prevalence of 26.4%, 24.1%, 5.3%, 8.4% and 22.4% for non-severe hypoglycemia, level 1, level 2, severe and nocturnal respectively. Patients with non-severe, severe, and nocturnal hypoglycemia
had more neuropathy, duration of diabetes, years with insulin, insulin u/kg, and fear of hypoglycemia. Patients with non-severe hypoglycemia also had more retinopathy and use of CGM. Patients with severe and nocturnal hypoglycemia also had a higher prevalence of insulin therapy. Regarding the prevalence of hypoglycemia in relation to the type of treatment: with insulin therapy: 52.4% and without insulin therapy: 16.6%. When we analyze the prevalence by level of hypoglycemia in those with insulin therapy was: 49.5%, 12.7%, 37.4% for non severe, severe and nocturnal hypoglycemia respectively. In patients without insulin was: 9.7%, 6.9%, 8.3% for non-severe, severe and nocturnal hypoglycemia respectively.

Conclusions: The prevalence of any hypoglycemic event in Comahue Chapter-SAD was high in the analyzed population. The events in our patients with T1D are similar to those reported in local studies. Associated factors were related to the years of diabetes, dose and time of insulin therapy, microvascular complications, fear of hypoglycemia and the use of CGM. Strategies should be sought to improve glycemic control and avoid the potential hypoglycemic risks.