Symposium 13: Impact of prediabetes on macrovascular disease
DOI:
https://doi.org/10.47196/diab.v56i3Sup.579Keywords:
diabetes mellitus, macrovascular diseaseAbstract
Macrovascular complications are often present at the time of diagnosis of type 2 diabetes: in a retrospective study that included 159,736 people newly diagnosed with diabetes, 23.5% had at least one macrovascular complication (coronary, cerebrovascular, and/or peripheral arterial disease)1.
Epidemiological studies have shown that prediabetes is a strong predictor of cardiovascular disease (CVD). In a meta-analysis including 53 prospective cohort studies with 1,611,339 individuals, with a follow-up of 9.5 years, prediabetes was associated with an increased risk of CVD, coronary heart disease, stroke and all-cause mortality compared with normoglycemia2. In this sense, the EPIC-Norfolk study showed that a 1% increase in HbA1c within the normal range was associated with greater cardiovascular mortality at ten years3.
References
I. Palladino R, Tabak AG, Khunti K, Valabhji J, Majeed A, Millett C, et al. Association between pre-diabetes and microvascular and macrovascular disease in newly diagnosed type 2 diabetes. BMJ Open Diabetes Res Care 2020 Apr;8(1). doi: 10.1136/bmjdrc-2019-001061
II. Huang Y, Cai X, Mai W, Li M, Hu Y. Association between prediabetes and risk of cardiovascular disease and all cause mortality: systematic review and meta-analysis. BMJ. 2016 Nov 23;355:i5953.
III. Brannick B, Wynn A, Dagogo-Jack S. Prediabetes as a toxic environment for the initiation of microvascular and macrovascular complications. Exp Biol Med 2016 Jun;241(12):1323-31.
IV. Brannick B, Dagogo-Jack S. Prediabetes and cardiovascular disease: pathophysiology and interventions for prevention and risk Reduction. Endocrinol Metab Clin North Am 2018 Mar;47(1):33-50.
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