Advantages and disadvantages of adopting the value at 60´ in the oral glucose tolerance test
Keywords:
diabetes, oral glucose tolerance testAbstract
The oral glucose tolerance test (OGTT) has been crucial in the detection of prediabetes and type 2 diabetes (T2DM) for over a century. However, there are currently debates about internationally acceptable cut-off points for defining intermediate hyperglycemia using fasting blood glucose, 2-hour post-load blood glucose (OGTT 2h), and HbA1c. Despite this, there is a global consensus on the use of OGTT 2h to define dysglycemic states.
Recently, the use of 1-hour blood glucose (OGTT 1h) during the OGTT has been proposed, as it could identify individuals at higher risk of progressing to T2DM and its complications, facilitating early interventions and potentially replacing the conventional 2-hour OGTT. Studies show that an OGTT 1h > 155 mg/dL in individuals with normal glucose tolerance is highly predictive of progression to T2DM, micro and macrovascular complications, and mortality.
The International Diabetes Federation (IDF) supports the use of OGTT 1h to identify those at higher risk of T2DM, arguing that it could replace current diagnostic criteria due to its better ability to identify individuals at risk. However, there are potential disadvantages, such as the need to standardize and validate this test before its global implementation. Despite these challenges, the evidence supports reevaluating diagnostic and screening strategies to include OGTT 1h, which could significantly improve the prevention and management of diabetes worldwide
References
I. Bergman M, Manco M, Satman I et al, International Diabetes Federation Position Statement on the 1-hour post-load plasma glucose for the diagnosis of intermediate hyperglycaemia and type 2 diabetes. Diabetes Research and Clinical Practice 2024;209.
II. Bergman M, Manco M, Sesti G et al. Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥155 mg/dl (8.6 mmol/l). Diabetes Res Clin Practice 2018;146:18-33.
III. Jagannathan R, Neves J, Dorcely B, et al. The Oral Glucose Tolerance Test: 100 Years Later. Diabetes, Metabl Syndr Obes 2020;13:3787-3805.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 on behalf of the authors. Reproduction rights: Argentine Society of Diabetes
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Dirección Nacional de Derecho de Autor, Exp. N° 5.333.129. Instituto Nacional de la Propiedad Industrial, Marca «Revista de la Sociedad Argentina de Diabetes - Asociación Civil» N° de concesión 2.605.405 y N° de disposición 1.404/13.
La Revista de la SAD está licenciada bajo Licencia Creative Commons Atribución – No Comercial – Sin Obra Derivada 4.0 Internacional.
Por otra parte, la Revista SAD permite que los autores mantengan los derechos de autor sin restricciones.
