Physiopathology of diabetic kidney disease

Authors

  • Fabiana Vázquez British Hospital, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v51i3.101

Keywords:

kidney disease caused by diabetes, hyperglycemia, podocytes, SGLT-1, SGLT-2, tubuloglomerular feedback, increase of intraglomerular pressure

Abstract

Kidney disease caused by diabetes is a microvascular compli- cation in which hemodynamic, metabolic changes, oxidative stress and inflammation increase occur in the kidneys. This determines an increase of the mesangial extracellular matrix, basement membrane thickness, loss of podocyte foot and tubu- lar cells disruption with fibrosis and proteinuria. The increase of receptors SGLT-1 and SGLT-2 expression, with the resulting and marked reduction of Na+ offer to the macula densa is wrongly construed as a reduction of plasmatic volume by the yuxta-glo- merular complex through the “tubuloglomerular feedback”, ge- nerating vasodilation of the afferent arterioles and the resulting increase in intraglomerular pressure. This changes the classical glomerular concept, interpreting that there may be an initial le- sion at the tubular level.

Author Biography

Fabiana Vázquez, British Hospital, Autonomous City of Buenos Aires, Argentina

Medical specialist in Nutrition, specialized in diabetes; Endocrinology Service of the British Hospital, Vicente López headquarters; Member of the Nephropathy Committee of the Argentine Diabetes Society

References

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Published

2023-01-10

How to Cite

Vázquez, F. (2023). Physiopathology of diabetic kidney disease. Journal of the Argentine Society of Diabetes, 51(3), 69–76. https://doi.org/10.47196/diab.v51i3.101

Issue

Vol. 51 No. 3 (2017): September/December 2017

Section

Conferences and congresses

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Dirección Nacional de Derecho de Autor, Exp. N° 5.333.129. Instituto Nacional de la Propiedad Industrial, Marca «Revista de la Sociedad Argentina de Diabetes - Asociación Civil» N° de concesión 2.605.405 y N° de disposición 1.404/13.

La Revista de la SAD está licenciada bajo Licencia Creative Commons Atribución – No Comercial – Sin Obra Derivada 4.0 Internacional.

Por otra parte, la Revista SAD permite que los autores mantengan los derechos de autor sin restricciones.

 

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