Symposium 10: Muscle

Authors

  • Juan M. Corvalán Italian Hospital of La Plata, La Plata, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i3Sup.350

Keywords:

insulin resistance, diabetes

Abstract

Symposium 10: Insulin resistance: from pathophysiology to treatment

Muscle

The main action of the insulin in the muscle is that of promoting the entrance of glucose to the myocyte through the glucose transporter type 4 (GLUT-4) and its storage as an energy reserve in the form of glycogen. This energy will be consumed, in its majority, by the own muscle. The glucose that enters the muscle follows two paths: glycogen synthesis and the generation of energy through the glycolysis. Insulin regulates the glycogen synthesis through the action on both anabolic (glycogen synthetase) and catabolic (glycogen phosphorylase) pathways.

Author Biography

Juan M. Corvalán, Italian Hospital of La Plata, La Plata, Province of Buenos Aires, Argentina

Doctor, specialist in Medical Clinic, specialized in Diabetes; Head of the Diabetes Section Hospital Italiano de La Plata

References

-1- Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance.

Physiol Rev 2018; 98:2133-2223.

-2- Etiopatogenia de la diabetes tipo 2 (parte 2) Costa Gil J.E.

-3- Aguiar de Matos M, et al. Exercise reduces cellular stress related to skeletal muscle

insulin resistance. Cell Stress and Chaperones 2014;19:263-270.

-4- Worton RW, et al. Defining anabolic resistance: implications for delivery of clinical care

nutrition. Curr Opin Crit Care 2018 Apr;24(2):124-130.

Published

2023-01-10

How to Cite

Corvalán, J. M. (2023). Symposium 10: Muscle. Journal of the Argentine Society of Diabetes, 54(3Sup), 44–44. https://doi.org/10.47196/diab.v54i3Sup.350

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