P54 Pre diabetes and arterial stiffness: its identification and posible pathogenesis

Abstract

Introduction: background: in the prediabetes stage (PreD), vascular lesion markers appear indicating the need for early identification and timely treatment.

Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis.

Materials and methods: Pulse wave velocity (PWV) was measured in 208 people   with FINDRISC ≥13 (57±8 years old, 68.7% women) and either normal glucose tolerance (NGT) or PreD.In each subgroup we identified those with/out insulin resistance (IR) measured throughout the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collectedfor all participants. PWV was compared between subgroups using independent t test.

Results: Women and men have comparable clinical and metabolic characteristics with obesity (BMI ≥30) and antihypertensive-statin treatment, almost half with either NGT or PreD. While 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), those with PreDrepresented 52%. PWV was significantly higher onlyin those with a complete picture of metabolic syndrome (MS).

Conclusions: PWV was significantly higher in people with a complete picture of MS. If clinicians were aware of this situation, they might make an early diagnosis and prescribe a healthylife-style to prevent development/progression of CVD and the negative impact on patients ́ quality of life and higher cost of care.