P48 Metabolic results after bariatric surgery in patients with type 2 diabetes and obesity

Authors

  • Julieta Michelli Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Daniela Faretta Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Felisa Vilches Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Yanina Soledad Oliva Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • María Clara Fritz Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Silvina Del Luca Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • María de Luján Calcagno Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Patricio Cal Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Tomás Jakob Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Rubén Lutfi Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • María Jimena Soutelo Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i3Sup.434

Keywords:

metabolic results, bariatric surgery, type 2 diabetes, obesity

Abstract

Introduction: In type 2 diabetic and obese patients it is frequently difficult to achieve weight and metabolic control goals with lifestyle changes and pharmacotherapy and sometimes accomplished by bariatric surgery (BS).

Objectives: to evaluate metabolic effects of BS in a diabetic and obese population.

Materials and methods: 56 patients were evaluated preoperative and postoperative (BS). Personal background, anthropometric measurements, blood pressure, body mass index (BMI), hemogram, hepatogram, glycemia, lipid profile, HbA1c and renal function were analyzed.Statistical analysis: Student’s and Mann-Whitney-Wilcoxon tests were applied. Spearman correlation coefficient was calculated. Values expressed in average ± standard deviation. Significant p< 0,05.

Results: The sample consisted of 35 female and 21 male with a mean age of 52±9,6. One anastomosis gastric bypass (OAGB) was performed in 29 patients and laparoscopic Roux en-Y gastric bypass (LRYGB) in 27. Pre and postoperative data was analyzed. Postoperative data with a time lapse between 3 to 79 months, average of 31.6. In the preoperative period 52% received insulin, 77% metformin, 23% IDPP4, 100% antihypertensive drugs and 69% lipid lowering therapies while in the postoperative group only 7% were still treated with insulin, 14% metformin, 11% IDPP4, 54% antihypertensive drugs and 31% lipid lowering therapies. During the follow up BMI decreased from 43,87±9,99 kg/m2 in preoperative period to 29,48±5,82 kg/m2 in postoperative period (p<0,0001). There were not significant differences in blood pressure. Regarding metabolic parameters a significant difference was observed: Glycemia (mg/dl) 149±58 vs 101±21(p<0,0001); HbA1c 8,14±2,5% vs 5,86±1,09(p<0,0001); Triglycerides (TG) (mg/dl)159±68 vs 106±60 (p< 0,0001); TG/HDL: 4,11±2 vs 2,14±1,45 (p< 0,0001); HDL(mg/dl) 41±10 vs 53±13(p<0,0001); no HDL(mg/dl) 140±39 vs 122±37 (p 0,007); uric acid 5,44±1,47 vs 4,74±1,04(p 0,0004). There was significant correlation between
time in months after surgery and TG (r 0,27 p 0,04) TG/HDL (r 0,34 p 0,01) levels. Statistical significant reduction was found in favor of OAGB vs LRYGB regard of BMI (p 0,02), TG (p 0,01), total cholesterol (p 0,01) y no HDL (p 0,03). Hypoglycemia was found in 3,5% post BS and anemia in 14,28%.

Conclusions: As seen by other authors we found enhancement with BS in BMI, metabolic parameters and less use of medications. There were not significant differences in blood pressure levels.

Author Biographies

Julieta Michelli, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinology and Metabolism Service

Daniela Faretta, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinology and Metabolism Service

Felisa Vilches, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinology and Metabolism Service

Yanina Soledad Oliva, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinology and Metabolism Service

María Clara Fritz, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinology and Metabolism Service

Silvina Del Luca, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Mathematics Chair

María de Luján Calcagno, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Mathematics Chair

Patricio Cal, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Surgery Service

Tomás Jakob, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Mathematics Chair

Rubén Lutfi, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinology and Metabolism Service

María Jimena Soutelo, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Endocrinologist, University of Buenos Aires (UBA), specialized in Diabetes, Endocrinology Service

Published

2023-01-10

How to Cite

Michelli, J., Faretta, D., Vilches, F., Oliva, Y. S., Fritz, M. C., Del Luca, S., Calcagno, M. de L., Cal, P., Jakob, T., Lutfi, R., & Soutelo, M. J. (2023). P48 Metabolic results after bariatric surgery in patients with type 2 diabetes and obesity. Journal of the Argentine Society of Diabetes, 54(3Sup), 153–153. https://doi.org/10.47196/diab.v54i3Sup.434

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