Symposium 6: HLA and Non-HLA genetic predisposition

Authors

  • Gloria Cerrone Faculty of Pharmacy and Biochemistry. Diabetes and Metabolism Laboratory. Institute of Immunology, Genetics and Metabolism (INIGEM, UBA-CONICET). "José de San Martín" Clinical Hospital, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i3Sup.297

Keywords:

diabetes, genetic

Abstract

Symposium 6: Autoimmune diabetes: heterogeneity in its clinical presentations

HLA and Non-HLA genetic predisposition

Type 1 diabetes is a multifactorial autoimmune disease. Genetic and environmental factors, and their interaction, influence multiple mechanisms that contribute to varying degrees of diabetes development and progression in every patient. 

Heterogeneity is due to its polygenic nature, that is, multiple genes interactions and the contribution of environmental factors that trigger the pathology. The most frequent genetic variations reflect heterogeneity in each manifestation: early or juvenile, adults aged between 20 and 40 years old or in patients with LADA (Latent Autoimmune Diabetes in Adults). 

Author Biography

Gloria Cerrone, Faculty of Pharmacy and Biochemistry. Diabetes and Metabolism Laboratory. Institute of Immunology, Genetics and Metabolism (INIGEM, UBA-CONICET). "José de San Martín" Clinical Hospital, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Associate Professor, Chair of Genetics, Faculty of Pharmacy and Biochemistry

References

- Redondo MJ, et al. The clinical consequences of heterogeneity within and between different diabetes types. Redondo MJ y cols. Diabetologia. 2020;63(10):2040-2048.

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Published

2023-01-10

How to Cite

Cerrone, G. (2023). Symposium 6: HLA and Non-HLA genetic predisposition. Journal of the Argentine Society of Diabetes, 54(3Sup), 30–30. https://doi.org/10.47196/diab.v54i3Sup.297

Issue

Vol. 54 No. 3Sup (2020): September/December 2020

Section

Symposium Part 2

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Dirección Nacional de Derecho de Autor, Exp. N° 5.333.129. Instituto Nacional de la Propiedad Industrial, Marca «Revista de la Sociedad Argentina de Diabetes - Asociación Civil» N° de concesión 2.605.405 y N° de disposición 1.404/13.

La Revista de la SAD está licenciada bajo Licencia Creative Commons Atribución – No Comercial – Sin Obra Derivada 4.0 Internacional.

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