P50 Short term glycemic control with a hybrid closed loop system in individuals with type 1 diabetes

Abstract

Background: Despite recent technological advances, optimal glycemic control remains a challenge in people with type 1 diabetes (T1D). Hybrid closed loop (HCL) system with algorithm-derived automated adjustment of insulin delivery aims to improve glycemic control.

Aim: To evaluate the effectiveness of HCL on glycemic control in subjects with T1D

Methods: Prospective observational registry, that included consecutive patients with T1D that initiated treatment with MiniMed™ 670G system in Argentina. Baseline and follow up visits at days 7, 28 and 90 days were carried out and data was downloaded in each visit.

Results: 31 patients were included (age: 31.4 ± 15.1, range 9-57), female 64.5%, previous use of SAP-PLGS 71% (n=22), baseline HbA1c 7.4 ± 1%. Time in range (TIR) between 70-180 mg/dl significantly increased from 65.9% at baseline to 77.1%, 76.3% and 76% at days 7, 28 and 90 respectively. Mean glucose levels were reduced from 162.1 at baseline to 152.1 mg/dl (p=0,003) at last visit. The coefficient of variation was also reduced from 34.8% to 32% (p=0,011). Sensor were time and Auto Mode use were 88.7% and 91.1% respectively, by the end of the study.

Conclusions: hybrid closed-loop system improved glycemic control and glycemic variability in children and adults living with T1D.