Cellular drugs transporters. The journey of the oral antidiabetics agents trough the organism

Authors

  • Héctor Alejandro Serra Faculty of Medical Sciences of the Argentine Catholic University (UCA), Autonomous City of Buenos Aires, Argentina
  • Cristian Suárez Cordo Argentine Diabetes Society (SAD), Autonomous City of Buenos Aires, Argentina
  • Jorge Alvariñas E. Tornú Hospital, Autonomous City of Buenos Aires, Argentina
  • Julio César Bragagnolo J.M. Hospital Ramos Mejía, Autonomous City of Buenos Aires, Argentina
  • Gustavo Daniel Frechtel Hospital de Clínicas José de San Martín, Autonomous City of Buenos Aires, Argentina
  • Pilar Cean Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina
  • Claudia Folino Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina
  • Analía Dagum Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina
  • Susana Salzberg Latin American Diabetes Association, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v51i4.40

Keywords:

cellular drug transport, pharmacokinetics, oral antidiabetics agents

Abstract

Type 2 diabetes mellitus requires multiple pharmacological treatment in order to achieve therapeutic goals and control comorbidities. Therefore, treatment leads to drug interaction. It means that the observed effects, whether therapeutic or adverse, are the result of the concomitant administration of two or more drugs given to a patient. This concept should be extended to foods, cosmetics and environmental substances. For many years, drug interactions were studied in a descriptive-empirical way, but in the last decades the participating mechanisms were hierarchized.

Pharmacokinetic interactions involve absorptive, distributive and elimination processes in which enzymes and transport molecules are involved. Nowadays there is an even greater interest in the latter as a source of interactions.

The purpose of this paper is to describe the transporters involved in the pharmacokinetics of oral antidiabetic agents , and in this way to realize if there could potentially be any interference when another drug is added. 

Author Biographies

Héctor Alejandro Serra, Faculty of Medical Sciences of the Argentine Catholic University (UCA), Autonomous City of Buenos Aires, Argentina

Professor of Pharmacology, Faculty of Medical Sciences (UCA); Prof. Regular Adjunct of Pharmacology, Faculty of Medicine, UBA

Cristian Suárez Cordo, Argentine Diabetes Society (SAD), Autonomous City of Buenos Aires, Argentina

Member of the Pharmacology Committe (SAD); Coordinator of the Diabetes Program, Municip. of San Martín; Coordinator of the Diabetes Department, Diego Thompson Hospital 

Jorge Alvariñas, E. Tornú Hospital, Autonomous City of Buenos Aires, Argentina

Doctor in Medicine; Nutrition Consultant Hospital E. Tornú; Member of the Pharmacy Committee of the SAD

Julio César Bragagnolo, J.M. Hospital Ramos Mejía, Autonomous City of Buenos Aires, Argentina

Specialist in Internal Medicine and Nutrition; Head of the Nutrition and Diabetes Departmente, J.M. Ramos Mejia Hospital; Assistant Professor and Associate of the University of Buenos Aires (UBA); Clinical Professor of Diabetes and Pharmacology, Mastery of Diabetes, University of Salvador (USAL); Member of the Pharmacology Committee (SAD)

Gustavo Daniel Frechtel, Hospital de Clínicas José de San Martín, Autonomous City of Buenos Aires, Argentina

Physician Specialist in Nutrition, Doctorate in the UBA; Associate Professor of the Nutrition Chair, Department of Medicine (UBA); Head of the Genetic Division of the Hospital de Clínicas (UBA); Head of the Nutrition and Diabetes Service, Syrian Lebanese Hospital; Member of the Pharmacy Committee of the SAD

Pilar Cean, Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina

Member of the SAD Pharmacology Committee

Claudia Folino, Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina

Member of the SAD Pharmacology Committee

Analía Dagum, Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina

Member of the SAD Pharmacology Committee

Susana Salzberg, Latin American Diabetes Association, Autonomous City of Buenos Aires, Argentina

Former Director of the Graduate School (1999-2000); Coordinator of the Working Group of the Latin American Diabetes Association (ALAD, 2013-2016)

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Published

2023-01-10

How to Cite

Serra, H. A., Suárez Cordo, C., Alvariñas, J., Bragagnolo, J. C., Frechtel, G. D., Cean, P., Folino, C., Dagum, A., & Salzberg, S. (2023). Cellular drugs transporters. The journey of the oral antidiabetics agents trough the organism. Journal of the Argentine Society of Diabetes, 51(4), 137–152. https://doi.org/10.47196/diab.v51i4.40

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