Evaluation of the hypothalamo-pituitary-adrenal axis using the cortisol awakening response test in patients with type 1 diabetes mellitus with and without depression: Multicenter Argentine Study (EMA-1)

Authors

  • Adriana Álvarez Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Andrea Kozak Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Lucas Costa National University of the Litoral, Santa Fe, Argentina
  • Guillermo Alzueta Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina
  • Juan Bauchi Naval Hospital Puerto Belgrano, Bahía Blanca, Province of Buenos Aires, Argentina
  • Claudia De Boni Private Clinic, Mar del Plata, Province of Buenos Aires, Argentina
  • Guillermo Dieuzeide Nuestra Sra. Del Carmen Hospital, Chacabuco, Province of Buenos Aires, Argentina
  • Olga Escobar Diagnos Private Center, Tucumán, Argentina
  • Teresita García Private Clinic, National University of Tucumán, Tucumán, Argentina
  • Patricia Mascaró Private Clinic, Comodoro Rivadavia, Chubut, Argentina
  • Olguita Vera Private Clinic, Río Gallegos, Santa Cruz, Argentina
  • Diego González University of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Bibiana Fabre University of Buenos Aires, Autonomous City of Buenos Aires, Argentina
  • Luis Grosembacher Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i3.454

Keywords:

type 1 diabetes mellitus, hypothalamus-pituitary-adrenal-axis, depression, glycemic control

Abstract

Introduction: depression (DP) has a high prevalence in patients with type 1 diabetes mellitus (DM1) and is associated with negative clinicals consequences like more cardiovascular morbimortality and chronic complications. There are few studies published about the dysregulation of hypothalamo-pituitary-adrenal axis (H-P-A) in DM1 with DP and the relation between DP and the Cortisol Awakening Response Test (CAR) with the glycemic control (GC).

Objectives: examine the functionality of the H-P-A axis using the Cortisol Awakening Response Test (CAR), in patients with DM1 (PD1) with and without DP. Determine the prevalence of DP in PD1 and examine if there is any relation between CAR and GC and DP and poorer GC.

Materials and methods: observational, prospective, national, multicenter study. Patients with DM1, older than 18 years old; Patient Health-9 questionnaire (PHQ-9) was used to diagnose DP and 2 samples of salivary cortisol, and blood samples for glycemia, glycated albumin and Hba1c.

Author Biographies

Adriana Álvarez, Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Staff Physician of the Endocrinology, Metabolism and Nuclear Medicine Service

Andrea Kozak, Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Biochemist; Technical Director of the Laboratory of Hormonal and Genetic Endocrinology of the Service of Endocrinology, Metabolism and Nuclear Medicine

Lucas Costa, National University of the Litoral, Santa Fe, Argentina

Bioengineer, Biostatistics Unit, Faculty of Medical Sciences

Guillermo Alzueta, Argentine Diabetes Society, Autonomous City of Buenos Aires, Argentina

Specialist in Endocrinology

Juan Bauchi, Naval Hospital Puerto Belgrano, Bahía Blanca, Province of Buenos Aires, Argentina

Medical specialist; consultant in Endocrinology, senior in Medical Clinic and Diabetes; Master in Psycho-Immuno-Neuro-Endocrinology; Private practice

Claudia De Boni, Private Clinic, Mar del Plata, Province of Buenos Aires, Argentina

Member of the Committee of Psychosocial Aspects of the Argentine Diabetes Society

Guillermo Dieuzeide, Nuestra Sra. Del Carmen Hospital, Chacabuco, Province of Buenos Aires, Argentina

Member of the Psychosocial Aspects Committee of the Argentine Diabetes Society; Chief Internal Medicine Division; Head of the Endocrinology and Diabetes Service

Olga Escobar, Diagnos Private Center, Tucumán, Argentina

Member of the Committee of Psychosocial Aspects of the Argentine Diabetes Society

Teresita García, Private Clinic, National University of Tucumán, Tucumán, Argentina

Member of the Committee of Psychosocial Aspects of the Argentine Diabetes Society

Patricia Mascaró, Private Clinic, Comodoro Rivadavia, Chubut, Argentina

Member of the Committee of Psychosocial Aspects of the Argentine Diabetes Society

Olguita Vera, Private Clinic, Río Gallegos, Santa Cruz, Argentina

Endocrinologist

Diego González, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Biochemist, Endocrinology Laboratory, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry

Bibiana Fabre, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Biochemist, Endocrinology Laboratory, Department of Clinical Biochemistry, Faculty of Pharmacy and Biochemistry

Luis Grosembacher, Italian Hospital of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Staff Physician, Endocrinology, Metabolism and Nuclear Medicine Service; Head of the Diabetes Section

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Published

2023-01-10

How to Cite

Álvarez, A., Kozak, A., Costa, L., Alzueta, G., Bauchi, J., De Boni, C., Dieuzeide, G., Escobar, O., García, T., Mascaró, P., Vera, O., González, D., Fabre, B., & Grosembacher, L. (2023). Evaluation of the hypothalamo-pituitary-adrenal axis using the cortisol awakening response test in patients with type 1 diabetes mellitus with and without depression: Multicenter Argentine Study (EMA-1). Journal of the Argentine Society of Diabetes, 54(3), 132–139. https://doi.org/10.47196/diab.v54i3.454

Issue

Vol. 54 No. 3 (2020): September/December 2020

Section

Original article

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