Symposium 17: To the rescue of the beta cell

Authors

  • Luis Emilio Flores Center for Experimental and Applied Endocrinology (CENEXA; National University of La Plata- National Council for Scientific and Technical Research, (CONICET) La Plata, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v54i3Sup.332

Keywords:

beta cell, diabetes

Abstract

Symposium 17: Beta Cell Failure

To the rescue of the beta cell

Pancreatic β cells are specialized to release insulin in the event of any increase in blood glucose through a complex, highly regulated mechanism that ensures the maintenance of their homeostasis. There are multiple genetic and environmental factors that threaten the functional integrity of β cells and are responsible for the progression from the normal state to prediabetes or type 2 diabetes mellitus (DM2).

Currently we have various pharmacological tools that can recover its secretory function, but none is capable of recovering its mass, which is why it is essential to prevent its loss. The consumption of unbalanced diets, particularly diets rich in beverages sweetened with high fructose syrup (DRF), promotes the breakdown of metabolic homeostasis and the emergence of a state of insulin resistance (IR) that already manifests itself in the stage of prediabetes.

References

-1- Vasiljević J, et al. The making of insulin in health and disease. Diabetologia 2020; 63: 1981-1989.

-2- Román CL, et al. Islet NADPH oxidase activity modulates β-cell mass and endocrine function in rats with fructose-induced oxidative stress. BBActa 2014; 1840: 3475-3482.

-3- Maiztegui B, et al. VMP1-related autophagy induced by a fructose-rich diet in β-cells: its prevention by incretins. Clin. Sci 2017; 131:673-687.

-4- Lean MEJ, et al. Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet 2019; 7:344-355.

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Published

2023-01-10

How to Cite

Flores, L. E. (2023). Symposium 17: To the rescue of the beta cell. Journal of the Argentine Society of Diabetes, 54(3Sup), 58–58. https://doi.org/10.47196/diab.v54i3Sup.332

Issue

Vol. 54 No. 3Sup (2020): September/December 2020

Section

Symposium Part 4

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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