Prevention and prediction in Diabetes Mellitus type 1

Authors

  • Alejandro De Dios Hospital de Clínicas Gral. José de San Martín, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/diab.v53i2Sup.228

Keywords:

diabetes, prevention

Abstract

Type 1 diabetes mellitus (DM1) is a disease characterized by the autoimmune destruction of the beta cell mediated by the attack of cytotoxic T lymphocytes and in which the autoantibodies (GADA, IAA, AI2A and ZnT8A) are markers of it. Since this disease has polygenic bases, the risk of developing DM1 is more frequent in first-degree relatives than in the general population.

Author Biography

Alejandro De Dios, Hospital de Clínicas Gral. José de San Martín, Autonomous City of Buenos Aires, Argentina

Genetic Division

References

- Skyler JS. Primary and secondary prevention of type 1 diabetes. Diabet Med 2013; 30: 161-169.

- Ziegler AG, Rewers M, Simell O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013; 309: 2473-2479.

- Jacobsen LM, Haller MJ, Schatz DA. Understanding pre-type 1 diabetes: the key to prevention. Frontiers in Endocrinology 2018; 9:70. Doi: 10.3389/fendo.2018.00070.

- Herold KC, Bundy BN, Long A, et al. An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes. N Engl J Med 2019 Jun 9. Doi: 10.1056/NEJMoa1902226.

Published

2023-01-10

How to Cite

De Dios, A. (2023). Prevention and prediction in Diabetes Mellitus type 1. Journal of the Argentine Society of Diabetes, 53(2Sup), 14. https://doi.org/10.47196/diab.v53i2Sup.228

Issue

Section

Conferences and congresses

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