Symposium 10: Liver
DOI:
https://doi.org/10.47196/diab.v54i3Sup.446Keywords:
liver, diabetesAbstract
Symposium 10: Insulin resistance: from pathophysiology to treatment
Liver
The liver plays a key role on the adjustment of glucose and lipids' metabolism. Excess of nutrients on diets and obesity produce insulin resistance, a state on which insulin fails to appropriately regulate hepatic metabolism, which may cause a glucose production excess.
There is evidence of an increase on glucose production and de novo lipogenesis in insulin-resistent individuals. The combination of glucotoxicity and lipotoxicity produce an inflammatory state that increases even more IR.
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Dirección Nacional de Derecho de Autor, Exp. N° 5.333.129. Instituto Nacional de la Propiedad Industrial, Marca «Revista de la Sociedad Argentina de Diabetes - Asociación Civil» N° de concesión 2.605.405 y N° de disposición 1.404/13.
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