Symposium 14: Preclinical stage
DOI:
https://doi.org/10.47196/diab.v54i3Sup.325Keywords:
diabetes, treatmentAbstract
Symposium 14: When does type 1 diabetes mellitus begin?
Preclinical stage
Type 1 diabetes mellitus is the prototypical form of the autoimmune mediated form of diabetes. Classically, T1D is classified as pre-symptomatic T1D, characterized by a decrease of the asymptomatic beta-cell mass, and symptomatic T1D, in which state the symptoms of hyperglycemia start showing. Alternatively, T1D can be subdivided into three stages: stage 1, characterized by the presence of autoantibodies and the lack of dysglycemia; stage 2, characterized by the presence of both autoantibodies and dysglycemia, and stage 3, in which symptoms begin to appear (symptomatic T1D). Tries of staging of autoimmune T1D are useful when people sign up for secondary prevention trials. Autoimmunity marked by the presence of autoantibodies directed toward autoantigens of beta-cells tends to be present months or years before the loss of beta-cells begins.
References
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- Merger SR, Leslie RD, Boehm BO. The broad clinical phenotype of type 1 diabetes at presentation. Diabet. Med. 2013, 30, 170–178.
- Towards AN. Earlier and Timely Diagnosis of Type 1 Diabetes: Is it Time to Change Criteria to Define Disease Onset? M. Battaglia, L. Nigi and F. Dotta. Curr Diab Rep 2015 15:115.
- Insel R, Dutta S, Hedrick J. Type 1 Diabetes: Disease Stratification. Biomed Hub 2017;2 (suppl 1):481131.
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